{"entity": "publication", "iuid": "f65a43527def4120aec8d616cd7bd4a7", "timestamp": "2026-08-20T20:38:54.860Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f65a43527def4120aec8d616cd7bd4a7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f65a43527def4120aec8d616cd7bd4a7"}}, "title": "Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts.", "authors": [{"family": "Molteni", "given": "Erika", "initials": "E", "orcid": "0000-0001-7773-8140", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1985f3f3735b43f2939b9cf9295d67c5.json"}}, {"family": "Astley", "given": "Christina M", "initials": "CM"}, {"family": "Ma", "given": "Wenjie", "initials": "W"}, {"family": "Sudre", "given": "Carole H", "initials": "CH"}, {"family": "Magee", "given": "Laura A", "initials": "LA"}, {"family": "Murray", "given": "Benjamin", "initials": "B"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Gomez", "given": "Maria F", "initials": "MF"}, {"family": "Tsereteli", "given": "Neli", "initials": "N"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Brownstein", "given": "John S", "initials": "JS"}, {"family": "Davies", "given": "Richard", "initials": "R"}, {"family": "Wolf", "given": "Jonathan", "initials": "J"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Ourselin", "given": "Sebastien", "initials": "S"}, {"family": "Steves", "given": "Claire J", "initials": "CJ"}, {"family": "Chan", "given": "Andrew T", "initials": "AT"}, {"family": "Modat", "given": "Marc", "initials": "M"}], "type": "journal article", "published": "2021-03-25", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "11", "issue": "1", "pages": "6928", "issn-l": "2045-2322"}, "abstract": "We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18-44 years) provided longitudinal (smartphone application, N = 1,170,315, n = 79 pregnant tested positive) and cross-sectional (web-based survey, N = 1,344,966, n = 134 pregnant tested positive) data, prospectively collected through self-participatory citizen surveillance in UK, Sweden and USA. Pregnant and non-pregnant were compared for frequencies of events, including SARS-CoV-2 testing, symptoms and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects. Pregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity, except for gastrointestinal symptoms. Pregnant were more likely to have received testing, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with syndromic severity in pregnant hospitalized. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant who were hospitalized. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 infection during pregnancy.", "doi": "10.1038/s41598-021-86452-3", "pmid": "33767292", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7994587"}, {"db": "pii", "key": "10.1038/s41598-021-86452-3"}], "notes": [], "created": "2026-08-20T09:05:22.071Z", "modified": "2026-08-20T09:05:22.150Z"}