{"entity": "publication", "iuid": "f4cff420ef75484c933530a1ade9a4b1", "timestamp": "2026-09-25T12:53:02.904Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f4cff420ef75484c933530a1ade9a4b1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f4cff420ef75484c933530a1ade9a4b1"}}, "title": "Rapid Construction of a Chloromethyl-Substituted Duocarmycin-like Prodrug.", "authors": [{"family": "Bengtsson", "given": "Christoffer", "initials": "C", "orcid": "0000-0003-0020-2449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f6144898d5fa4e3d8027a6c47f9d53c8.json"}}, {"family": "Gravenfors", "given": "Ylva", "initials": "Y", "orcid": "0000-0001-6025-4908", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40ea78e284e947cdbd0d176e4cbb880c.json"}}], "type": "journal article", "published": "2023-06-16", "journal": {"title": "Molecules", "issn": "1420-3049", "volume": "28", "issue": "12", "issn-l": "1420-3049"}, "abstract": "The construction of duocarmycin-like compounds is often associated with lengthy synthetic routes. Presented herein is the development of a short and convenient synthesis of a type of duocarmycin prodrug. The 1,2,3,6-tetrahydropyrrolo[3,2-e]indole-containing core is here constructed from commercially available Boc-5-bromoindole in four steps and 23% overall yield, utilizing a Buchwald-Hartwig amination followed by a sodium hydride-induced regioselective bromination. In addition, protocols for selective mono- and di-halogenations of positions 3 and 4 were also developed, which could be useful for further exploration of this scaffold.", "doi": "10.3390/molecules28124818", "pmid": "37375372", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10304315"}, {"db": "pii", "key": "molecules28124818"}], "notes": [], "created": "2026-09-23T15:27:40.063Z", "modified": "2026-09-23T15:27:40.120Z"}