{"entity": "publication", "iuid": "f2e073c539964cb99421973720314a69", "timestamp": "2026-09-28T11:20:09.234Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f2e073c539964cb99421973720314a69.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f2e073c539964cb99421973720314a69"}}, "title": "The TGFB2-AS1 lncRNA Regulates TGF-\u03b2 Signaling by Modulating Corepressor Activity.", "authors": [{"family": "Papoutsoglou", "given": "Panagiotis", "initials": "P"}, {"family": "Tsubakihara", "given": "Yutaro", "initials": "Y"}, {"family": "Caja", "given": "Laia", "initials": "L"}, {"family": "Mor\u00e9n", "given": "Anita", "initials": "A"}, {"family": "Pallis", "given": "Paris", "initials": "P"}, {"family": "Ameur", "given": "Adam", "initials": "A"}, {"family": "Heldin", "given": "Carl-Henrik", "initials": "CH"}, {"family": "Moustakas", "given": "Aristidis", "initials": "A"}], "type": "journal article", "published": "2019-09-17", "journal": {"title": "Cell Reports", "issn": "2211-1247", "volume": "28", "issue": "12", "pages": "3182-3198.e11", "issn-l": null}, "abstract": "Molecular processes involving lncRNAs regulate cell function. By applying transcriptomics, we identify lncRNAs whose expression is regulated by transforming growth factor \u03b2 (TGF-\u03b2). Upon silencing individual lncRNAs, we identify several that regulate TGF-\u03b2 signaling. Among these lncRNAs, TGFB2-antisense RNA1 (TGFB2-AS1) is induced by TGF-\u03b2 through Smad and protein kinase pathways and resides in the nucleus. Depleting TGFB2-AS1 enhances TGF-\u03b2/Smad-mediated transcription and expression of hallmark TGF-\u03b2-target genes. Increased dose of TGFB2-AS1 reduces expression of these genes, attenuates TGF-\u03b2-induced cell growth arrest, and alters BMP and Wnt pathway gene profiles. Mechanistically, TGFB2-AS1, mainly via its 3' terminal region, binds to the EED adaptor of the Polycomb repressor complex 2 (PRC2), promoting repressive histone H3K27me3 modifications at TGF-\u03b2-target gene promoters. Silencing EED or inhibiting PRC2 methylation activity partially rescues TGFB2-AS1-mediated gene repression. Thus, the TGF-\u03b2-induced TGFB2-AS1 lncRNA exerts inhibitory functions on TGF-\u03b2/BMP signaling output, supporting auto-regulatory negative feedback that balances TGF-\u03b2/BMP-mediated responses.", "doi": "10.1016/j.celrep.2019.08.028", "pmid": "31533040", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6859500"}, {"db": "pii", "key": "S2211-1247(19)31062-9"}], "notes": [], "created": "2026-09-23T09:33:59.648Z", "modified": "2026-09-23T09:33:59.678Z"}