{"entity": "publication", "iuid": "f23bcd6e649d411aae2672d4b06d1663", "timestamp": "2026-09-28T11:15:23.560Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f23bcd6e649d411aae2672d4b06d1663.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f23bcd6e649d411aae2672d4b06d1663"}}, "title": "Reduced sialyl-Lewisx on salivary MUC7 from patients with burning mouth syndrome.", "authors": [{"family": "Acharya", "given": "Shikha", "initials": "S"}, {"family": "Jin", "given": "Chunsheng", "initials": "C"}, {"family": "Bylund", "given": "Johan", "initials": "J"}, {"family": "Shen", "given": "Qiujin", "initials": "Q"}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M"}, {"family": "Jontell", "given": "Mats", "initials": "M"}, {"family": "Carl\u00e9n", "given": "Anette", "initials": "A"}, {"family": "Karlsson", "given": "Niclas G", "initials": "NG"}], "type": "journal article", "published": "2019-10-07", "journal": {"title": "Mol Omics", "issn": "2515-4184", "volume": "15", "issue": "5", "pages": "331-339", "issn-l": null}, "abstract": "We analysed and compared MUC7 O-glycosylation and inflammatory biomarkers in saliva from female patients with burning mouth syndrome (BMS) and gender/age-matched controls. Oligosaccharides from salivary MUC7 from BMS and controls were released. Inflammatory mediators were measured by multiplex proximity extension assay. Presence of sialyl-Lewisx (Si-Lex) epitope on MUC7 was confirmed using Western blot. MUC7 O-glycans and measured inflammatory biomarkers were found to be similar between BMS and controls. However, oligosaccharides sialyl-Lewisx (Si-Lex) was found to be reduced in samples from BMS patients. Positive correlation (combined patients and controls) was found between levels of C-C motif chemokine 19 (CCL-19) and the amount of core-2 oligosaccharides on MUC7 as well as fractalkine (CX3CL1) and level of sialylation. Patients with BMS were shown to represent a heterogeneous group in terms of inflammatory biomarkers. This indicates that BMS patients could be further stratified on the basis of low-level inflammation. The results furthermore indicate that reduced sialylation of MUC7, particularly Si-Lex, may be an important feature in patients with BMS. However, the functional aspects and potential involvement in immune regulation of Si-Lex remains unclear. Our data suggests a chemokine driven alteration of MUC7 glycosylation.", "doi": "10.1039/c9mo00061e", "pmid": "31414088", "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T12:49:29.349Z", "modified": "2026-09-23T12:49:29.377Z"}