{"entity": "publication", "iuid": "f1651733b59a4c768b41daa20f04d951", "timestamp": "2026-08-22T08:30:27.857Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f1651733b59a4c768b41daa20f04d951.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f1651733b59a4c768b41daa20f04d951"}}, "title": "Revisiting the Role of \u03b3\u03b4 T Cells in Anti-CMV Immune Response after Transplantation.", "authors": [{"family": "Gaballa", "given": "Ahmed", "initials": "A", "orcid": "0000-0002-5277-5129", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b062c2e7638440919938a93892cf7848.json"}}, {"family": "Alagrafi", "given": "Faisal", "initials": "F"}, {"family": "Uhlin", "given": "Michael", "initials": "M", "orcid": "0000-0002-2177-6727", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/116cfe482bb941159ee2e7175f1cd095.json"}}, {"family": "Stikvoort", "given": "Arwen", "initials": "A"}], "type": "journal article", "published": "2021-05-29", "journal": {"title": "Viruses", "issn": "1999-4915", "volume": "13", "issue": "6", "issn-l": "1999-4915"}, "abstract": "Gamma delta (\u03b3\u03b4) T cells form an unconventional subset of T lymphocytes that express a T cell receptor (TCR) consisting of \u03b3 and \u03b4 chains. Unlike conventional \u03b1\u03b2 T cells, \u03b3\u03b4 T cells share the immune signature of both the innate and the adaptive immunity. These features allow \u03b3\u03b4 T cells to act in front-line defense against infections and tumors, rendering them an attractive target for immunotherapy. The role of \u03b3\u03b4 T cells in the immune response to cytomegalovirus (CMV) has been the focus of intense research for several years, particularly in the context of transplantation, as CMV reactivation remains a major cause of transplant-related morbidity and mortality. Therefore, a better understanding of the mechanisms that underlie CMV immune responses could enable the design of novel \u03b3\u03b4 T cell-based therapeutic approaches. In this regard, the advent of next-generation sequencing (NGS) and single-cell TCR sequencing have allowed in-depth characterization of CMV-induced TCR repertoire changes. In this review, we try to shed light on recent findings addressing the adaptive role of \u03b3\u03b4 T cells in CMV immunosurveillance and revisit CMV-induced TCR reshaping in the era of NGS. Finally, we will demonstrate the favorable and unfavorable effects of CMV reactive \u03b3\u03b4 T cells post-transplantation.", "doi": "10.3390/v13061031", "pmid": "34072610", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8228273"}, {"db": "pii", "key": "v13061031"}], "notes": [], "created": "2026-08-21T13:05:13.840Z", "modified": "2026-08-21T13:05:13.910Z"}