{"entity": "publication", "iuid": "f005dcf41be94886948499f6c48e7e41", "timestamp": "2026-08-20T20:45:26.463Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f005dcf41be94886948499f6c48e7e41.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f005dcf41be94886948499f6c48e7e41"}}, "title": "Spatial transcriptomics reveals an unexpected impact of tau and tau pathology on the expression of transthyretin.", "authors": [{"family": "Croteau", "given": "Deborah L", "initials": "DL"}, {"family": "Navarro", "given": "Jose Fernandez", "initials": "JF"}, {"family": "Comptdaer", "given": "Thomas", "initials": "T"}, {"family": "Andrusivova", "given": "Zaneta", "initials": "Z"}, {"family": "Jurek", "given": "Aleksandra", "initials": "A"}, {"family": "Bonnefoy", "given": "Eliette", "initials": "E"}, {"family": "Bu\u00e9e", "given": "Luc", "initials": "L"}, {"family": "Bohr", "given": "Vilhelm A", "initials": "VA"}, {"family": "Lundeberg", "given": "Joakim", "initials": "J"}, {"family": "Galas", "given": "Marie-Christine", "initials": "MC"}], "type": "journal article", "published": "2025-10-31", "journal": {"title": "Front Aging Neurosci", "issn": "1663-4365", "volume": "17", "pages": "1656850", "issn-l": null}, "abstract": "RNA expression is modulated by tau. We used two mouse models, THY-Tau22 mice, which express pro-aggregation tau, and TauKO mice, which are null for tau, to improve our understanding of tau-altered mRNA expression in brain.\n\nSpatial transcriptomics on Tau22 and TauKO mice were used to interrogate regional mRNA expression changes. We focused on mRNA expression changes in the hippocampus and ventricles; two regions altered early in Alzheimer's disease.\n\nWe identified the transthyretin mRNA, Ttr, as being dysregulated in a tau-dependent manner. Immunofluorescence (IF) revealed increased TTR protein expression in THY-Tau22 mice and lowered expression in TauKO mice in the choroid plexus epithelial cells.\n\nAs TTR is involved in the clearance of A\u03b2 and the prevention of A\u03b2 aggregation, we evaluated endogenous mouse A\u03b2 in TauKO mice and observed increased A\u03b2 deposits. Our study reveals a hitherto unknown regulatory role of tau on Ttr mRNA and protein expression, which may participate in a feedback loop contributing to A\u03b2 disease progression.", "doi": "10.3389/fnagi.2025.1656850", "pmid": "41245137", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12615506"}], "notes": [], "created": "2026-08-20T13:07:37.947Z", "modified": "2026-08-20T13:07:37.980Z"}