{"entity": "publication", "iuid": "ef4f7e2f0e0d4764a14157bd3c599937", "timestamp": "2026-03-17T00:38:43.065Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ef4f7e2f0e0d4764a14157bd3c599937.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ef4f7e2f0e0d4764a14157bd3c599937"}}, "title": "Evidence of streptococcal origin of acute non-necrotising cellulitis: a serological study.", "authors": [{"family": "Karppelin", "given": "M", "initials": "M"}, {"family": "Siljander", "given": "T", "initials": "T"}, {"family": "Haapala", "given": "A-M", "initials": "AM"}, {"family": "Aittoniemi", "given": "J", "initials": "J"}, {"family": "Huttunen", "given": "R", "initials": "R"}, {"family": "Kere", "given": "J", "initials": "J"}, {"family": "Vuopio", "given": "J", "initials": "J"}, {"family": "Syrj\u00e4nen", "given": "J", "initials": "J"}], "type": "journal article", "published": "2015-04-00", "journal": {"title": "Eur. J. Clin. Microbiol. Infect. Dis.", "issn": "1435-4373", "volume": "34", "issue": "4", "pages": "669-672", "issn-l": "0934-9723"}, "abstract": "Bacteriological diagnosis is rarely achieved in acute cellulitis. Beta-haemolytic streptococci and Staphylococcus aureus are considered the main pathogens. The role of the latter is, however, unclear in cases of non-suppurative cellulitis. We conducted a serological study to investigate the bacterial aetiology of acute non-necrotising cellulitis. Anti-streptolysin O (ASO), anti-deoxyribonuclease B (ADN) and anti-staphylolysin (ASTA) titres were measured from acute and convalescent phase sera of 77 patients hospitalised because of acute bacterial non-necrotising cellulitis and from the serum samples of 89 control subjects matched for age and sex. Antibiotic treatment decisions were also reviewed. Streptococcal serology was positive in 53 (69%) of the 77 cases. Furthermore, ten cases without serological evidence of streptococcal infection were successfully treated with penicillin. Positive ASO and ADN titres were detected in ten (11%) and three (3%) of the 89 controls, respectively, and ASTA was elevated in three patients and 11 controls. Our findings suggest that acute non-necrotising cellulitis without pus formation is mostly of streptococcal origin and that penicillin can be used as the first-line therapy for most patients.", "doi": "10.1007/s10096-014-2274-9", "pmid": "25403372", "labels": {"Affiliated researcher": null}, "xrefs": [], "notes": [], "created": "2018-12-05T09:58:56.424Z", "modified": "2018-12-05T09:58:56.455Z"}