{"entity": "publication", "iuid": "ed5aaec5f5784efb92e7b32200c0117c", "timestamp": "2026-08-29T04:37:13.442Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ed5aaec5f5784efb92e7b32200c0117c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ed5aaec5f5784efb92e7b32200c0117c"}}, "title": "Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex.", "authors": [{"family": "Chen", "given": "Ao", "initials": "A"}, {"family": "Sun", "given": "Yidi", "initials": "Y"}, {"family": "Lei", "given": "Ying", "initials": "Y"}, {"family": "Li", "given": "Chao", "initials": "C"}, {"family": "Liao", "given": "Sha", "initials": "S"}, {"family": "Meng", "given": "Juan", "initials": "J"}, {"family": "Bai", "given": "Yiqin", "initials": "Y"}, {"family": "Liu", "given": "Zhen", "initials": "Z"}, {"family": "Liang", "given": "Zhifeng", "initials": "Z"}, {"family": "Zhu", "given": "Zhiyong", "initials": "Z"}, {"family": "Yuan", "given": "Nini", "initials": "N"}, {"family": "Yang", "given": "Hao", "initials": "H"}, {"family": "Wu", "given": "Zihan", "initials": "Z"}, {"family": "Lin", "given": "Feng", "initials": "F"}, {"family": "Wang", "given": "Kexin", "initials": "K"}, {"family": "Li", "given": "Mei", "initials": "M"}, {"family": "Zhang", "given": "Shuzhen", "initials": "S"}, {"family": "Yang", "given": "Meisong", "initials": "M"}, {"family": "Fei", "given": "Tianyi", "initials": "T"}, {"family": "Zhuang", "given": "Zhenkun", "initials": "Z"}, {"family": "Huang", "given": "Yiming", "initials": "Y"}, {"family": "Zhang", "given": "Yong", "initials": "Y"}, {"family": "Xu", "given": "Yuanfang", "initials": "Y"}, {"family": "Cui", "given": "Luman", "initials": "L"}, {"family": "Zhang", "given": "Ruiyi", "initials": "R"}, {"family": "Han", "given": "Lei", "initials": "L"}, {"family": "Sun", "given": "Xing", "initials": "X"}, {"family": "Chen", "given": "Bichao", "initials": "B"}, {"family": "Li", "given": "Wenjiao", "initials": "W"}, {"family": "Huangfu", "given": "Baoqian", "initials": "B"}, {"family": "Ma", "given": "Kailong", "initials": "K"}, {"family": "Ma", "given": "Jianyun", "initials": "J"}, {"family": "Li", "given": "Zhao", "initials": "Z"}, {"family": "Lin", "given": "Yikun", "initials": "Y"}, {"family": "Wang", "given": "He", "initials": "H"}, {"family": "Zhong", "given": "Yanqing", "initials": "Y"}, {"family": "Zhang", "given": "Huifang", "initials": "H"}, {"family": "Yu", "given": "Qian", "initials": "Q"}, {"family": "Wang", "given": "Yaqian", "initials": "Y"}, {"family": "Liu", "given": "Xing", "initials": "X"}, {"family": "Peng", "given": "Jian", "initials": "J"}, {"family": "Liu", "given": "Chuanyu", "initials": "C"}, {"family": "Chen", "given": "Wei", "initials": "W"}, {"family": "Pan", "given": "Wentao", "initials": "W"}, {"family": "An", "given": "Yingjie", "initials": "Y"}, {"family": "Xia", "given": "Shihui", "initials": "S"}, {"family": "Lu", "given": "Yanbing", "initials": "Y"}, {"family": "Wang", "given": "Mingli", "initials": "M"}, {"family": "Song", "given": "Xinxiang", "initials": "X"}, {"family": "Liu", "given": "Shuai", "initials": "S"}, {"family": "Wang", "given": "Zhifeng", "initials": "Z"}, {"family": "Gong", "given": "Chun", "initials": "C"}, {"family": "Huang", "given": "Xin", "initials": "X"}, {"family": "Yuan", "given": "Yue", "initials": "Y"}, {"family": "Zhao", "given": "Yun", "initials": "Y"}, {"family": "Chai", "given": "Qinwen", "initials": "Q"}, {"family": "Tan", "given": "Xing", "initials": "X"}, {"family": "Liu", "given": "Jianfeng", "initials": "J"}, {"family": "Zheng", "given": "Mingyuan", "initials": "M"}, {"family": "Li", "given": "Shengkang", "initials": "S"}, {"family": "Huang", "given": "Yaling", "initials": "Y"}, {"family": "Hong", "given": "Yan", "initials": "Y"}, {"family": "Huang", "given": "Zirui", "initials": "Z"}, {"family": "Li", "given": "Min", "initials": "M"}, {"family": "Jin", "given": "Mengmeng", "initials": "M"}, {"family": "Li", "given": "Yan", "initials": "Y"}, {"family": "Zhang", "given": "Hui", "initials": "H"}, {"family": "Sun", "given": "Suhong", "initials": "S"}, {"family": "Gao", "given": "Li", "initials": "L"}, {"family": "Bai", "given": "Yinqi", "initials": "Y"}, {"family": "Cheng", "given": "Mengnan", "initials": "M"}, {"family": "Hu", "given": "Guohai", "initials": "G"}, {"family": "Liu", "given": "Shiping", "initials": "S"}, {"family": "Wang", "given": "Bo", "initials": "B"}, {"family": "Xiang", "given": "Bin", "initials": "B"}, {"family": "Li", "given": "Shuting", "initials": "S"}, {"family": "Li", "given": "Huanhuan", "initials": "H"}, {"family": "Chen", "given": "Mengni", "initials": "M"}, {"family": "Wang", "given": "Shiwen", "initials": "S"}, {"family": "Li", "given": "Minglong", "initials": "M"}, {"family": "Liu", "given": "Weibin", "initials": "W"}, {"family": "Liu", "given": "Xin", "initials": "X"}, {"family": "Zhao", "given": "Qian", "initials": "Q"}, {"family": "Lisby", "given": "Michael", "initials": "M"}, {"family": "Wang", "given": "Jing", "initials": "J"}, {"family": "Fang", "given": "Jiao", "initials": "J"}, {"family": "Lin", "given": "Yun", "initials": "Y"}, {"family": "Xie", "given": "Qing", "initials": "Q"}, {"family": "He", "given": "Jie", "initials": "J"}, {"family": "Xu", "given": "Huatai", "initials": "H"}, {"family": "Huang", "given": "Wei", "initials": "W"}, {"family": "Mulder", "given": "Jan", "initials": "J"}, {"family": "Yang", "given": "Huanming", "initials": "H"}, {"family": "Sun", "given": "Yangang", "initials": "Y"}, {"family": "Uhlen", "given": "Mathias", "initials": "M"}, {"family": "Poo", "given": "Muming", "initials": "M"}, {"family": "Wang", "given": "Jian", "initials": "J"}, {"family": "Yao", "given": "Jianhua", "initials": "J"}, {"family": "Wei", "given": "Wu", "initials": "W"}, {"family": "Li", "given": "Yuxiang", "initials": "Y"}, {"family": "Shen", "given": "Zhiming", "initials": "Z"}, {"family": "Liu", "given": "Longqi", "initials": "L"}, {"family": "Liu", "given": "Zhiyong", "initials": "Z"}, {"family": "Xu", "given": "Xun", "initials": "X"}, {"family": "Li", "given": "Chengyu", "initials": "C"}], "type": "journal article", "published": "2023-08-17", "journal": {"title": "Cell", "issn": "1097-4172", "volume": "186", "issue": "17", "pages": "3726-3743.e24", "issn-l": "0092-8674"}, "abstract": "Elucidating the cellular organization of the cerebral cortex is critical for understanding brain structure and function. Using large-scale single-nucleus RNA sequencing and spatial transcriptomic analysis of 143 macaque cortical regions, we obtained a comprehensive atlas of 264 transcriptome-defined cortical cell types and mapped their spatial distribution across the entire cortex. We characterized the cortical layer and region preferences of glutamatergic, GABAergic, and non-neuronal cell types, as well as regional differences in cell-type composition and neighborhood complexity. Notably, we discovered a relationship between the regional distribution of various cell types and the region's hierarchical level in the visual and somatosensory systems. Cross-species comparison of transcriptomic data from human, macaque, and mouse cortices further revealed primate-specific cell types that are enriched in layer 4, with their marker genes expressed in a region-dependent manner. Our data provide a cellular and molecular basis for understanding the evolution, development, aging, and pathogenesis of the primate brain.", "doi": "10.1016/j.cell.2023.06.009", "pmid": "37442136", "labels": [], "xrefs": [{"db": "pii", "key": "S0092-8674(23)00679-7"}], "notes": [], "created": "2026-08-20T06:50:23.288Z", "modified": "2026-08-20T06:50:23.299Z"}