{"entity": "publication", "iuid": "eb0019b4540a4bb498c62a3f990cb363", "timestamp": "2026-10-01T11:59:44.800Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/eb0019b4540a4bb498c62a3f990cb363.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/eb0019b4540a4bb498c62a3f990cb363"}}, "title": "Aberrant expression of SLAMF6 constitutes a targetable immune escape mechanism in acute myeloid leukemia.", "authors": [{"family": "Sand\u00e9n", "given": "Carl", "initials": "C", "orcid": "0000-0002-8931-9565", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f6c6db4e0904bc79ff50b0891e9d317.json"}}, {"family": "Landberg", "given": "Niklas", "initials": "N", "orcid": "0000-0001-6752-6507", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e4a8eed87af4b24b7ad2f541f6527bf.json"}}, {"family": "Pe\u00f1a-Mart\u00ednez", "given": "Pablo", "initials": "P", "orcid": "0000-0002-0789-6431", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4124eeca91774b76a33fee201abb00db.json"}}, {"family": "Thorsson", "given": "Hanna", "initials": "H", "orcid": "0000-0001-5393-2942", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/12e66968f211411bbfe3a19714b18b22.json"}}, {"family": "Daga", "given": "Shruti", "initials": "S"}, {"family": "Puente-Moncada", "given": "Noelia", "initials": "N"}, {"family": "Rodriguez-Zabala", "given": "Maria", "initials": "M"}, {"family": "von Palffy", "given": "Sofia", "initials": "S"}, {"family": "Rissler", "given": "Marianne", "initials": "M"}, {"family": "Lazarevic", "given": "Vladimir", "initials": "V", "orcid": "0000-0002-1782-4423", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f33c39109f2469fad15c5265560be69.json"}}, {"family": "Juliusson", "given": "Gunnar", "initials": "G"}, {"family": "Ohlin", "given": "Mats", "initials": "M", "orcid": "0000-0002-5105-1938", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/85422da1f8c441f7848c4850abef7555.json"}}, {"family": "Hyrenius-Wittsten", "given": "Axel", "initials": "A"}, {"family": "Orsmark-Pietras", "given": "Christina", "initials": "C", "orcid": "0000-0002-6533-0305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55df5f5ab99940a6a018ff0aa1c0b758.json"}}, {"family": "Lilljebj\u00f6rn", "given": "Henrik", "initials": "H", "orcid": "0000-0001-8703-1173", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/83d3c8e64bb5452a9a6332c0a21a5a51.json"}}, {"family": "\u00c5gerstam", "given": "Helena", "initials": "H"}, {"family": "Fioretos", "given": "Thoas", "initials": "T", "orcid": "0000-0002-3235-6154", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/34c176e18c654f5d9adc7b360640ced8.json"}}], "type": "journal article", "published": "2025-11-00", "journal": {"title": "Nat Cancer", "issn": "2662-1347", "volume": "6", "issue": "11", "pages": "1821-1838", "issn-l": null}, "abstract": "Immunotherapy has shown limited success in acute myeloid leukemia (AML), indicating an incomplete understanding of the underlying immunoregulatory mechanisms. Here we identify an immune evasion mechanism present in 60% of AML cases, wherein primitive AML cells aberrantly express the lymphoid surface protein SLAMF6 (signaling lymphocyte activation molecule family member 6). Knockout of SLAMF6 in AML cells enables T cell activation and highly efficient killing of leukemia cells in coculture systems, demonstrating that SLAMF6 protects AML cells from recognition and elimination by the immune system in a mode analogous to the programmed cell death protein-ligand (PDL1/PD1) axis. Targeting SLAMF6 with an antibody against the SLAMF6 dimerization site inhibits the SLAMF6-SLAMF6 interaction and induces T cell activation and killing of AML cells both in vitro and in humanized in vivo models. In conclusion, we show that aberrant expression of SLAMF6 is a common and targetable immune escape mechanism that could pave the way for immunotherapy in AML.", "doi": "10.1038/s43018-025-01054-6", "pmid": "41044242", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12643940"}, {"db": "pii", "key": "10.1038/s43018-025-01054-6"}], "notes": [], "created": "2026-10-01T08:27:05.219Z", "modified": "2026-10-01T08:27:05.367Z"}