{"entity": "publication", "iuid": "ea65973eb62745228452d39173864144", "timestamp": "2026-08-26T22:48:29.966Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ea65973eb62745228452d39173864144.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ea65973eb62745228452d39173864144"}}, "title": "Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis.", "authors": [{"family": "d'Alessandro", "given": "Elisa", "initials": "E"}, {"family": "Becker", "given": "Christian", "initials": "C"}, {"family": "Bergmeier", "given": "Wolfgang", "initials": "W"}, {"family": "Bode", "given": "Christoph", "initials": "C"}, {"family": "Bourne", "given": "Joshua H", "initials": "JH"}, {"family": "Brown", "given": "Helena", "initials": "H"}, {"family": "Buller", "given": "Harry R", "initials": "HR"}, {"family": "Ten Cate-Hoek", "given": "Arina J", "initials": "AJ"}, {"family": "Ten Cate", "given": "Vincent", "initials": "V"}, {"family": "van Cauteren", "given": "Yvonne J M", "initials": "YJM"}, {"family": "Cheung", "given": "Yam F H", "initials": "YFH"}, {"family": "Cleuren", "given": "Audrey", "initials": "A"}, {"family": "Coenen", "given": "Danielle", "initials": "D"}, {"family": "Crijns", "given": "Harry J G M", "initials": "HJGM"}, {"family": "de Simone", "given": "Ilaria", "initials": "I"}, {"family": "Dolleman", "given": "Sophie C", "initials": "SC"}, {"family": "Klein", "given": "Christine Espinola", "initials": "CE"}, {"family": "Fernandez", "given": "Delia I", "initials": "DI"}, {"family": "Granneman", "given": "Lianne", "initials": "L"}, {"family": "van T Hof", "given": "Arnoud", "initials": "A"}, {"family": "Henke", "given": "Peter", "initials": "P"}, {"family": "Henskens", "given": "Yvonne M C", "initials": "YMC"}, {"family": "Huang", "given": "Jingnan", "initials": "J"}, {"family": "Jennings", "given": "Lisa K", "initials": "LK"}, {"family": "Jooss", "given": "Natalie", "initials": "N"}, {"family": "Karel", "given": "Mieke", "initials": "M"}, {"family": "van den Kerkhof", "given": "Danique", "initials": "D"}, {"family": "Klok", "given": "Frederik A", "initials": "FA"}, {"family": "Kremers", "given": "Bram", "initials": "B"}, {"family": "L\u00e4mmle", "given": "Bernhard", "initials": "B"}, {"family": "Leader", "given": "Avi", "initials": "A"}, {"family": "Lundstrom", "given": "Annika", "initials": "A"}, {"family": "Mackman", "given": "Nigel", "initials": "N"}, {"family": "Mannucci", "given": "Pier M", "initials": "PM"}, {"family": "Maqsood", "given": "Zahra", "initials": "Z"}, {"family": "van der Meijden", "given": "Paola E J", "initials": "PEJ"}, {"family": "van Moorsel", "given": "Marc", "initials": "M"}, {"family": "Moran", "given": "Luis A", "initials": "LA"}, {"family": "Morser", "given": "John", "initials": "J"}, {"family": "van Mourik", "given": "Manouk", "initials": "M"}, {"family": "Navarro", "given": "Stefano", "initials": "S"}, {"family": "Neagoe", "given": "Raluca A I", "initials": "RAI"}, {"family": "Olie", "given": "Renske H", "initials": "RH"}, {"family": "van Paridon", "given": "Pauline", "initials": "P"}, {"family": "Posma", "given": "Jens", "initials": "J"}, {"family": "Provenzale", "given": "Isabella", "initials": "I"}, {"family": "Reitsma", "given": "Pieter H", "initials": "PH"}, {"family": "Scaf", "given": "Billy", "initials": "B"}, {"family": "Schurgers", "given": "Leon", "initials": "L"}, {"family": "Seelig", "given": "Jaap", "initials": "J"}, {"family": "Siegbahn", "given": "Agneta", "initials": "A"}, {"family": "Siegerink", "given": "Bob", "initials": "B"}, {"family": "Soehnlein", "given": "Oliver", "initials": "O"}, {"family": "Soriano", "given": "Eva Maria", "initials": "EM"}, {"family": "Sowa", "given": "Marcin A", "initials": "MA"}, {"family": "Spronk", "given": "Henri M H", "initials": "HMH"}, {"family": "Storey", "given": "Robert F", "initials": "RF"}, {"family": "Tantiwong", "given": "Chukiat", "initials": "C"}, {"family": "Veninga", "given": "Alicia", "initials": "A"}, {"family": "Wang", "given": "Xueqing", "initials": "X"}, {"family": "Watson", "given": "Steve P", "initials": "SP"}, {"family": "Weitz", "given": "Jeff", "initials": "J"}, {"family": "Zeerleder", "given": "Sacha S", "initials": "SS"}, {"family": "Ten Cate", "given": "Hugo", "initials": "H"}, {"family": "Scientific Reviewer Committee", "given": "", "initials": ""}], "type": "consensus statement", "published": "2020-04-00", "journal": {"title": "Thromb. Haemost.", "issn": "2567-689X", "volume": "120", "issue": "4", "pages": "538-564", "issn-l": "0340-6245"}, "abstract": "Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.", "doi": "10.1055/s-0040-1708035", "pmid": "32289858", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T11:59:12.764Z", "modified": "2026-08-21T11:59:12.782Z"}