{"entity": "publication", "iuid": "e9d0f5ffc3744bd6965d3555e3a215cb", "timestamp": "2026-08-26T22:47:01.815Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e9d0f5ffc3744bd6965d3555e3a215cb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e9d0f5ffc3744bd6965d3555e3a215cb"}}, "title": "PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage.", "authors": [{"family": "Ahmed", "given": "Wareed", "initials": "W"}, {"family": "Lingner", "given": "Joachim", "initials": "J"}], "type": "journal article", "published": "2020-11-03", "journal": {"title": "Cell Reports", "issn": "2211-1247", "volume": "33", "issue": "5", "pages": "108347", "issn-l": null}, "abstract": "Telomeres are prone to damage inflicted by reactive oxygen species (ROS). Oxidized telomeric DNA and nucleotide substrates inhibit telomerase, causing telomere shortening. In addition, ROS can induce telomeric single-strand DNA breaks (SSBs). The peroxiredoxin-PRDX1 is enriched in telomeric chromatin and this counteracts ROS-induced telomere damage. Here, we identify DNA processing after oxidative stress as a main source of telomeric DNA cleavage events in the absence of PRDX1. In PRDX1-depleted cells, poly(ADP-ribose) polymerase (PARP)-dependent telomeric repair is often incomplete, giving persistent SSBs that are converted into telomeric double-strand breaks during replication, leading to rapid telomere shortening. Interestingly, PARP1 inhibition dampens telomere shortening, triggering stabilization of the homologous recombination (HR) factor BRCA1 and RAD51-mediated repair of telomeres. Overall, our results reveal that, in the absence PRDX1, incomplete PARP1-dependent DNA repair and competition between PARP1 and HR cause ROS-induced telomeric catastrophe.", "doi": "10.1016/j.celrep.2020.108347", "pmid": "33147465", "labels": [], "xrefs": [{"db": "pii", "key": "S2211-1247(20)31336-X"}], "notes": [], "created": "2026-08-21T11:15:59.199Z", "modified": "2026-08-21T11:15:59.219Z"}