{"entity": "publication", "iuid": "e85843dff49849398e34f9ec6c00640a", "timestamp": "2026-09-24T14:45:08.512Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e85843dff49849398e34f9ec6c00640a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e85843dff49849398e34f9ec6c00640a"}}, "title": "A feasibility randomised controlled trial of a brief early intervention for adolescent depression that targets emotional mental images and memory specificity (IMAGINE).", "authors": [{"family": "Pile", "given": "Victoria", "initials": "V"}, {"family": "Smith", "given": "Patrick", "initials": "P"}, {"family": "Leamy", "given": "Mary", "initials": "M"}, {"family": "Oliver", "given": "Abigail", "initials": "A"}, {"family": "Bennett", "given": "Eleanor", "initials": "E"}, {"family": "Blackwell", "given": "Simon E", "initials": "SE"}, {"family": "Meiser-Stedman", "given": "Richard", "initials": "R"}, {"family": "Stringer", "given": "Dominic", "initials": "D"}, {"family": "Dunn", "given": "Barnaby D", "initials": "BD"}, {"family": "Holmes", "given": "Emily A", "initials": "EA"}, {"family": "Lau", "given": "Jennifer Y F", "initials": "JYF"}], "type": "journal article", "published": "2021-08-00", "journal": {"title": "Behav Res Ther", "issn": "1873-622X", "volume": "143", "pages": "103876", "issn-l": null}, "abstract": "Brief, evidence-based interventions for adolescent depression are urgently required, particularly for school-settings. Cognitive mechanisms research suggests dysfunctional mental imagery and overgeneral memory could be promising targets to improve mood. This feasibility randomised controlled trial with parallel symptomatic groups (n = 56) compared a novel imagery-based cognitive behavioural intervention (ICBI) to non-directive supportive therapy (NDST) in school settings. Blind assessments (of clinical symptoms and cognitive mechanisms) took place pre-intervention, post-intervention and follow-up three months later. The trial aimed to evaluate the feasibility and acceptability of the methodology and interventions, and estimate the likely range of effects of the intervention on self-reported depression. The pre-defined criteria for proceeding to a definitive RCT were met: full recruitment occurred within eleven months; retention was 89%; ICBI acceptability was above satisfactory; and no harm was indicated. Intention-to-treat analysis found large effects in favour of ICBI (relative to NDST) at post-intervention in reducing depressive symptoms (d = -1.34, 95% CI [-1.87, -0.80]) and improving memory specificity (d = 0.79 [0.35, 1.23]), a key cognitive target. The findings suggest that ICBI may not only improve mood but also strengthen abilities associated with imagining and planning the future, critical skills at this life stage. A fully powered evaluation of ICBI is warranted. Trial Registration: https://www.isrctn.com/; ISRCTN85369879.", "doi": "10.1016/j.brat.2021.103876", "pmid": "34098409", "labels": [], "xrefs": [{"db": "pii", "key": "S0005-7967(21)00075-9"}, {"db": "ISRCTN", "key": "ISRCTN85369879"}], "notes": [], "created": "2026-09-23T09:35:40.820Z", "modified": "2026-09-23T09:35:40.855Z"}