{"entity": "publication", "iuid": "e6cf6be6f69a484996603372c40c196f", "timestamp": "2026-09-25T23:03:39.417Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e6cf6be6f69a484996603372c40c196f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e6cf6be6f69a484996603372c40c196f"}}, "title": "Autoantibodies to protein S may explain rare cases of coagulopathy following COVID-19 vaccination.", "authors": [{"family": "Yalcinkaya", "given": "Ahmet", "initials": "A"}, {"family": "Cavalli", "given": "Marco", "initials": "M"}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M"}, {"family": "Cederholm", "given": "Axel", "initials": "A"}, {"family": "G\u00fcner", "given": "Almira", "initials": "A"}, {"family": "Rietrae", "given": "Isabel", "initials": "I"}, {"family": "Mildner", "given": "Hedvig", "initials": "H"}, {"family": "Behere", "given": "Anish", "initials": "A"}, {"family": "Eriksson", "given": "Oskar", "initials": "O"}, {"family": "Gonzalez", "given": "Laura", "initials": "L"}, {"family": "Mugabo", "given": "Constantin Habimana", "initials": "CH"}, {"family": "Johnsson", "given": "Anette", "initials": "A"}, {"family": "Lakshmikanth", "given": "Tadepally", "initials": "T"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Wadelius", "given": "Mia", "initials": "M"}, {"family": "Hallberg", "given": "P\u00e4r", "initials": "P"}, {"family": "Landegren", "given": "Nils", "initials": "N"}], "type": "journal article", "published": "2024-10-18", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "14", "issue": "1", "pages": "24512", "issn-l": "2045-2322"}, "abstract": "While Coronavirus disease 2019 (COVID-19) vaccines have proven to be both effective and generally safe, rare but severe adverse events following immunization (AEFIs) are described. Autoantibodies to platelet factor-4 are associated with catastrophic thrombotic AEFIs, but comprehensive investigations of other autoantibodies are lacking. We aimed to detect and describe autoantibodies targeting coagulation-related proteins in a population-wide cohort (SWEDEGENE) including AEFIs attributed to COVID-19 vaccines in Sweden. Subjects were recruited from December 2020 to October 2022 and were stratified based on diagnosis and COVID-19 exposure. Screening was carried out in two phases, with a multiplex bead-based assay in the first subset (until September 2021) and with targeted assays for the second (until October 2022). Positivity was defined based on absolute, relative, and biological/technical thresholds. Patients with coagulation-related AEFIs were older and the Vaxzevria vaccine was overrepresented in this group. Two cases had antiphospholipid antibodies but none had PF4 antibodies. We identified six positives for protein S autoantibodies. Protein S concentrations were negatively correlated with autoantibody response in patients with immunoreactivity and functional analysis revealed low protein S activity in three subjects. Our population-wide analysis reveals cases with autoantibodies against protein S which possibly underlie coagulopathic AEFIs.", "doi": "10.1038/s41598-024-75514-x", "pmid": "39424883", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11489816"}, {"db": "pii", "key": "10.1038/s41598-024-75514-x"}], "notes": [], "created": "2026-09-23T13:15:38.992Z", "modified": "2026-09-23T13:15:39.005Z"}