{"entity": "publication", "iuid": "e5972dc4a89e40d7b1b468731731b045", "timestamp": "2026-09-01T08:24:46.588Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e5972dc4a89e40d7b1b468731731b045.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e5972dc4a89e40d7b1b468731731b045"}}, "title": "Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity.", "authors": [{"family": "Wallmann", "given": "Tatjana", "initials": "T"}, {"family": "Zhang", "given": "Xing-Mei", "initials": "XM"}, {"family": "Wallerius", "given": "Majken", "initials": "M"}, {"family": "Bolin", "given": "Sara", "initials": "S"}, {"family": "Joly", "given": "Anne-Laure", "initials": "AL"}, {"family": "Sobocki", "given": "Caroline", "initials": "C"}, {"family": "Leiss", "given": "Lina", "initials": "L"}, {"family": "Jiang", "given": "Yiwen", "initials": "Y"}, {"family": "Bergh", "given": "Jonas", "initials": "J"}, {"family": "Holland", "given": "Eric C", "initials": "EC"}, {"family": "Enger", "given": "Per \u00d8", "initials": "P\u00d8"}, {"family": "Andersson", "given": "John", "initials": "J"}, {"family": "Swartling", "given": "Fredrik J", "initials": "FJ"}, {"family": "Miletic", "given": "Hrvoje", "initials": "H"}, {"family": "Uhrbom", "given": "Lene", "initials": "L"}, {"family": "Harris", "given": "Robert A", "initials": "RA"}, {"family": "Rolny", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2018-11-30", "journal": {"title": "iScience", "issn": "2589-0042", "volume": "9", "pages": "71-83", "issn-l": null}, "abstract": "High-grade gliomas (HGGs) are the most aggressive and invasive primary brain tumors. The platelet-derived growth factor (PDGF) signaling pathway drives HGG progression, and enhanced expression of PDGF receptors (PDGFRs) is a well-established aberration in a subset of glioblastomas (GBMs). PDGFRA is expressed in glioma cells, whereas PDGFRB is mostly restricted to the glioma-associated stroma. Here we show that the spatial location of TAMMs correlates with the expansion of a subset of tumor cells that have acquired expression of PDGFRB in both mouse and human low-grade glioma and HCGs. Furthermore, M2-polarized microglia but not bone marrow (BM)-derived macrophages (BMDMs) induced PDGFRB expression in glioma cells and stimulated their migratory capacity. These findings illustrate a heterotypic cross-talk between microglia and glioma cells that may enhance the migratory and invasive capacity of the latter by inducing PDGFRB.", "doi": "10.1016/j.isci.2018.10.011", "pmid": "30384135", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6214839"}, {"db": "pii", "key": "S2589-0042(18)30170-6"}], "notes": [], "created": "2026-08-20T07:57:27.891Z", "modified": "2026-08-20T07:57:27.935Z"}