{"entity": "publication", "iuid": "de73a09405f94bda810509b75392f030", "timestamp": "2026-08-26T22:47:32.713Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/de73a09405f94bda810509b75392f030.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/de73a09405f94bda810509b75392f030"}}, "title": "Characterization of anti-BCG benz[\u03b1]anthraquinones and new siderophores from a Xinjiang desert-isolated rare actinomycete Nocardia sp. XJ31.", "authors": [{"family": "Zhang", "given": "Li", "initials": "L"}, {"family": "Zhang", "given": "Jingyu", "initials": "J"}, {"family": "Ren", "given": "Biao", "initials": "B"}, {"family": "Lu", "given": "Wanying", "initials": "W"}, {"family": "Hou", "given": "Chengjian", "initials": "C"}, {"family": "Wang", "given": "Jian", "initials": "J"}, {"family": "Ma", "given": "Xiaolong", "initials": "X"}, {"family": "Ma", "given": "Rong", "initials": "R"}, {"family": "Liu", "given": "Mei", "initials": "M"}, {"family": "Liu", "given": "Zhiheng", "initials": "Z"}, {"family": "Li", "given": "Jin-Ping", "initials": "JP"}, {"family": "Ding", "given": "Kan", "initials": "K"}, {"family": "Dai", "given": "Huanqin", "initials": "H"}, {"family": "Zhang", "given": "Lixin", "initials": "L"}, {"family": "Liu", "given": "Xueting", "initials": "X"}], "type": "journal article", "published": "2020-10-00", "journal": {"title": "Appl. Microbiol. Biotechnol.", "issn": "1432-0614", "volume": "104", "issue": "19", "pages": "8267-8278", "issn-l": "0175-7598"}, "abstract": "The current global demand for novel anti-TB drugs has drawn urgent attention on the discovery of natural product compounds with anti-TB activity. Lots of efforts have emphasized on environmental samples from unexplored or underexplored natural habits and identified numerous rare actinomycete taxa producing structurally diverse bioactive natural products. Herein, we report a survey of the rare actinobacteria diversity in Xinjiang region together with the discovery of anti-TB active natural products from these strains. We have collected 17 soil samples at different sites with different environmental conditions, from which 39 rare actinobacteria were identified by using a selective isolation strategy with 5 media variations. Among those isolated strains, XJ31 was identified as a new Nocardia sp. based on 16S rRNA gene analysis. Through one strain-many compounds (OSMAC) strategy combined with anti-Bacillus Calmette-Gu\u00e9rin bioassay-guided isolation, two groups of compounds were identified. They were twelve siderophores (nocardimicins, 1-12) and two anthraquinones (brasiliquinones, 13 and 14) and ten of them were identified as new compounds. The structures of the purified compounds were elucidated using HR-ESI-MS, 1D NMR, and 2D NMR techniques. The anti-TB bioassays revealed that the two benz[\u03b1]anthraquinones have potent activity against BCG (MICs = 25 \u03bcM), which can be used as a promising start point for further anti-TB drug development. KEY POINTS: \u2022 Ten new natural products were identified from Nocardia sp. XJ31. \u2022 Brasiliquinones 13 and 14 showed moderate anti-BCG activity.", "doi": "10.1007/s00253-020-10842-2", "pmid": "32830291", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7443361"}, {"db": "pii", "key": "10.1007/s00253-020-10842-2"}], "notes": [], "created": "2026-08-21T11:06:13.065Z", "modified": "2026-08-21T11:06:13.094Z"}