{"entity": "publication", "iuid": "dd8e1d1f044d42cebdf0de3f9ad845b5", "timestamp": "2026-08-20T20:42:22.420Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/dd8e1d1f044d42cebdf0de3f9ad845b5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/dd8e1d1f044d42cebdf0de3f9ad845b5"}}, "title": "Elevated levels of IL-12/IL-23p40 in Nova Scotia Duck Tolling Retrievers with autoimmune disease and lymphoma.", "authors": [{"family": "Nilsson", "given": "Malin", "initials": "M"}, {"family": "Kozyrev", "given": "Sergey V", "initials": "SV"}, {"family": "Saellstr\u00f6m", "given": "Sara", "initials": "S"}, {"family": "Johansson", "given": "Siri", "initials": "S"}, {"family": "Andersson", "given": "G\u00f6ran", "initials": "G"}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K"}, {"family": "Hansson-Hamlin", "given": "Helene", "initials": "H"}, {"family": "R\u00f6nnberg", "given": "Henrik", "initials": "H"}], "type": "journal article", "published": "2024-05-21", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "14", "issue": "1", "pages": "11624", "issn-l": "2045-2322"}, "abstract": "The Nova Scotia Duck Tolling Retriever (NSDTR) is predisposed to immune mediated rheumatic disease (IMRD), steroid-responsive meningitis-arteritis (SRMA) and certain forms of cancer. Cytokines are the main regulators of the immune system. Interleukin 2 is a cytokine involved in activation of T regulatory cells, playing a role in central tolerance and tumor immunity. Interleukin 12 and interleukin 23 share the same subunit, p40, and are both pro-inflammatory cytokines. The aim of this study was to compare levels of IL-2 in healthy NSDTRs to those with cancer or autoimmune disease and to compare levels of IL-12/IL-23p40 in healthy NSDTRs and beagles versus NSDTRs with cancer or autoimmune disease. 62 dogs were included in the analysis of IL-12/IL-23p40; healthy NSDTRs (n = 16), healthy beagles (n = 16), NSDTRs autoimmune (n = 18) and NDSTRs lymphoma/mastocytoma (n = 12) and 68 dogs for IL-2; healthy (n = 20), autoimmune (n = 36) and lymphoma/mastocytoma/adenocarcinoma (n = 12). NSDTRs with autoimmune disease had higher levels of IL-12/IL-23p40 compared to healthy dogs (p = 0.008). NSDTRs with lymphoma also had higher levels of IL-12/IL-23p40 compared to healthy NSDTRs (p = 0.002). There was no difference in levels of IL-2 between healthy and diseased NSDTR. Statistical analysis was performed using Bonferroni corrections for multiple testing. These findings can contribute to the knowledge of autoimmune disease and cancer in dogs.", "doi": "10.1038/s41598-024-62265-y", "pmid": "38773194", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11109178"}, {"db": "pii", "key": "10.1038/s41598-024-62265-y"}], "notes": [], "created": "2026-08-20T09:23:52.762Z", "modified": "2026-08-20T09:23:52.809Z"}