{"entity": "publication", "iuid": "dba0a7dcc7f9459f866534c3961321e3", "timestamp": "2026-10-01T12:00:03.020Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/dba0a7dcc7f9459f866534c3961321e3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/dba0a7dcc7f9459f866534c3961321e3"}}, "title": "HUBMet: an integrative database and analytical platform for human blood metabolites and metabolite-protein associations.", "authors": [{"family": "Wang", "given": "Xingyue", "initials": "X"}, {"family": "Qiao", "given": "Xiangyu", "initials": "X"}, {"family": "Zenere", "given": "Alberto", "initials": "A"}, {"family": "Barde", "given": "Swapnali", "initials": "S"}, {"family": "Wang", "given": "Jing", "initials": "J"}, {"family": "Zhong", "given": "Wen", "initials": "W"}], "type": "journal article", "published": "2025-12-27", "journal": {"title": "Genome Biol.", "issn": "1474-760X", "volume": "27", "issue": "1", "pages": "7", "issn-l": "1474-7596"}, "abstract": "Understanding human blood metabolites is essential for deciphering systemic physiology and disease mechanisms, yet remains challenging due to diverse origins and dynamic regulation. In this study, we develop HUBMet ( https://hubmet.app.bio-it.tech/home ), an open-access web server that includes 3,950 metabolites and 129,814 metabolite-protein associations, with four analytical modules: Over-Representation Analysis (ORA) for enrichment analysis; Metabolite Set Enrichment Analysis (MSEA) for quantitative data analysis; Tissue Specificity Analysis (TSA) for assessing metabolite-tissue relevance; Metabolite-Protein Network Analysis (MPNet) for identifying key metabolite-protein associations and functional modules. HUBMet's utility is demonstrated through a COVID-19 case study revealing metabolic signatures associated with disease severity.", "doi": "10.1186/s13059-025-03922-x", "pmid": "41455991", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12838415"}, {"db": "pii", "key": "10.1186/s13059-025-03922-x"}], "notes": [], "created": "2026-10-01T08:36:48.754Z", "modified": "2026-10-01T08:36:48.769Z"}