{"entity": "publication", "iuid": "daaccc704a2d4190ace6f34418b6877e", "timestamp": "2026-08-20T21:31:40.965Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/daaccc704a2d4190ace6f34418b6877e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/daaccc704a2d4190ace6f34418b6877e"}}, "title": "Thoracolumbar meningeal fibrosis in pugs.", "authors": [{"family": "Rohdin", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-7698-550X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22e03664ae6048dfb63792efbcd91649.json"}}, {"family": "Ljungvall", "given": "Ingrid", "initials": "I"}, {"family": "H\u00e4ggstr\u00f6m", "given": "Jens", "initials": "J", "orcid": "0000-0003-3402-023X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72f5852ea390478a8f8dcaa0a4d8390c.json"}}, {"family": "Leijon", "given": "Alexandra", "initials": "A"}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K"}, {"family": "Matiasek", "given": "Kaspar", "initials": "K"}, {"family": "Rosati", "given": "Marco", "initials": "M"}, {"family": "Wohlsein", "given": "Peter", "initials": "P"}, {"family": "J\u00e4derlund", "given": "Karin Hultin", "initials": "KH"}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "J. Vet. Intern. Med.", "issn": "1939-1676", "volume": "34", "issue": "2", "pages": "797-807", "issn-l": "0891-6640"}, "abstract": "Thoracolumbar myelopathies associated with spinal cord and vertebral column lesions, with a similar clinical phenotype, but different underlying etiologies, occur in pugs.\n\nTo further characterize the clinical and neuropathological characteristics of pugs with longstanding thoracolumbar myelopathy.\n\nThirty client-owned pure-bred pugs with a history of more than a month of ataxia and paresis of the pelvic limbs, suggesting a myelopathy localized to the thoracolumbar spinal cord, were included in the study.\n\nProspective clinicopathological study. Included pugs underwent a complete neurological examination and gross and histopathologic postmortem studies with focus on the spinal cord. Computed tomography (n = 18), magnetic resonance imaging (n = 17), and cerebrospinal fluid analysis (n = 27) were performed before or immediately after death.\n\nTwenty male and 10 female pugs had a median age at clinical onset of 84 months (interquartile range, 66-96). Affected pugs presented with a progressive clinical course and 80% were incontinent. There was circumferential meningeal fibrosis with concomitant focal, malacic, destruction of the neuroparenchyma in the thoracolumbar spinal cord in 24/30 pugs. Vertebral lesions accompanied the focal spinal cord lesion, and there was lympho-histiocytic inflammation associated or not to the parenchymal lesion in 43% of the pugs.\n\nMeningeal fibrosis with associated focal spinal cord destruction and neighboring vertebral column lesions were common findings in pugs with long-standing thoracolumbar myelopathy.", "doi": "10.1111/jvim.15716", "pmid": "32003496", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7096664"}], "notes": [], "created": "2026-08-20T11:18:44.733Z", "modified": "2026-08-20T11:18:44.843Z"}