{"entity": "publication", "iuid": "d449f0a4fad642e59027b725b02ef124", "timestamp": "2026-08-20T21:35:01.501Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d449f0a4fad642e59027b725b02ef124.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d449f0a4fad642e59027b725b02ef124"}}, "title": "Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgf\u03b2 Signaling in the Tumor Microenvironment.", "authors": [{"family": "Zhang", "given": "Yanyu", "initials": "Y", "orcid": "0000-0001-9939-1838", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33cec15d087243bcb0a9b6ff967a8a05.json"}}, {"family": "Manouchehri Doulabi", "given": "Ehsan", "initials": "E", "orcid": "0000-0003-1639-2267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad12164c3f004575b93f26cf83df40eb.json"}}, {"family": "Herre", "given": "Melanie", "initials": "M"}, {"family": "Cedervall", "given": "Jessica", "initials": "J"}, {"family": "Qiao", "given": "Qi", "initials": "Q"}, {"family": "Miao", "given": "Zuoxiu", "initials": "Z"}, {"family": "Hamidi", "given": "Anahita", "initials": "A", "orcid": "0000-0002-5445-2446", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c9d2a9063065410385248b810cc9790f.json"}}, {"family": "Hellman", "given": "Lars", "initials": "L", "orcid": "0000-0003-1459-3815", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8880fe8eb1847faba04190c7f9a76cf.json"}}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M", "orcid": "0000-0002-1303-2218", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/70fceb2370d74e39a8c26d17963981cc.json"}}, {"family": "Olsson", "given": "Anna-Karin", "initials": "AK"}], "type": "journal article", "published": "2022-04-12", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "14", "issue": "8", "issn-l": "2072-6694"}, "abstract": "Platelets constitute a major reservoir of platelet-derived growth factor B (PDGFB) and are continuously activated in the tumor microenvironment, exposing tumors to the plethora of growth factors contained in platelet granules. To address the specific role of platelet-derived PDGFB in the tumor microenvironment, we have created a mouse model with conditional knockout of PDGFB in platelets (pl-PDGFB KO). Lack of PDGFB in platelets resulted in 10-fold lower PDGFB concentration in the tumor microenvironment, fewer cancer-associated fibroblasts and reduced deposition of the extracellular matrix (ECM) molecules fibronectin and collagen I in the orthotopic RIP1-Tag2 model for pancreatic neuroendocrine cancer. Myosin light chain phosphorylation, promoting cell contraction and, consequently, the mechano-induced release of active transforming growth factor (TGF) \u03b2 from extracellular compartments, was reduced in tumors from pl-PDGFB KO mice. In agreement, TGF\u03b2 signaling, measured as phosphorylated Smad2, was significantly hampered in tumors from mice lacking PDGFB in their platelets, providing a plausible explanation for the reduced deposition of extracellular matrix. These findings indicate a major contribution of platelet-derived PDGFB to a malignant transformation of the tumor microenvironment and address for the first time the role of PDGFB released specifically from platelets in the remodeling of the ECM in tumors.", "doi": "10.3390/cancers14081947", "pmid": "35454853", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9024906"}, {"db": "pii", "key": "cancers14081947"}], "notes": [], "created": "2026-08-20T13:39:45.836Z", "modified": "2026-08-20T13:39:46.014Z"}