{"entity": "publication", "iuid": "d310db99173e424a8629440f6610b70c", "timestamp": "2026-09-01T08:24:52.675Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d310db99173e424a8629440f6610b70c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d310db99173e424a8629440f6610b70c"}}, "title": "The Long Noncoding RNA LINC00958 Is Induced in Psoriasis Epidermis and Modulates Epidermal Proliferation.", "authors": [{"family": "Luo", "given": "Longlong", "initials": "L"}, {"family": "Pasquali", "given": "Lorenzo", "initials": "L"}, {"family": "Srivastava", "given": "Ankit", "initials": "A"}, {"family": "Freisenhausen", "given": "Jan C", "initials": "JC"}, {"family": "Pivarcsi", "given": "Andor", "initials": "A"}, {"family": "Sonkoly", "given": "Enik\u00f6", "initials": "E"}], "type": "journal article", "published": "2023-06-00", "journal": {"title": "J. Invest. Dermatol.", "issn": "1523-1747", "volume": "143", "issue": "6", "pages": "999-1010", "issn-l": "0022-202X"}, "abstract": "Psoriasis is a common, immune-mediated skin disease characterized by epidermal hyperproliferation and chronic skin inflammation. Long noncoding RNAs are >200 nucleotide-long transcripts that possess important regulatory functions. To date, little is known about the contribution of long noncoding RNAs to psoriasis. In this study, we identify LINC00958 as a long noncoding RNA overexpressed in keratinocytes (KCs) from psoriasis skin lesions, in a transcriptomic screen performed on KCs sorted from psoriasis and healthy skin. Increased levels of LINC00958 in psoriasis KCs were confirmed by RT-qPCR and single-molecule in situ hybridization. Confocal microscopy and analysis of subcellular fractions showed that LINC00958 is mainly localized in the cytoplasm of KCs. IL-17A, a key psoriasis cytokine, induced LINC00958 in KCs through C/EBP-\u03b2 and the p38 pathway. The inhibition of LINC00958 led to decreased proliferation as measured by Ki-67 expression, live cell analysis imaging, and 5-ethynyl-2-deoxyuridine assays. Transcriptomic analysis of LINC00958-depleted KCs revealed enrichment of proliferation- and cell cycle\u2012related genes among differentially expressed transcripts. Moreover, LINC00958 depletion led to decreased basal and IL-17A\u2012induced phosphorylation of p38. Furthermore, IL-17A\u2012induced KC proliferation was counteracted by the inhibition of LINC00958. In summary, our data support a role for the IL-17A\u2012induced long noncoding RNA, LINC00958, in the pathological circuits of psoriasis by reinforcing IL-17A\u2012induced epidermal hyperproliferation.", "doi": "10.1016/j.jid.2022.12.011", "pmid": "36641130", "labels": [], "xrefs": [{"db": "pii", "key": "S0022-202X(22)02905-0"}], "notes": [], "created": "2026-08-21T11:22:25.862Z", "modified": "2026-08-21T11:22:25.888Z"}