{"entity": "publication", "iuid": "d1ac0986e88a4624a7903a4f5932d819", "timestamp": "2026-09-28T11:18:24.058Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d1ac0986e88a4624a7903a4f5932d819.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d1ac0986e88a4624a7903a4f5932d819"}}, "title": "Xist ribonucleoproteins promote female sex-biased autoimmunity.", "authors": [{"family": "Dou", "given": "Diana R", "initials": "DR"}, {"family": "Zhao", "given": "Yanding", "initials": "Y"}, {"family": "Belk", "given": "Julia A", "initials": "JA"}, {"family": "Zhao", "given": "Yang", "initials": "Y"}, {"family": "Casey", "given": "Kerriann M", "initials": "KM"}, {"family": "Chen", "given": "Derek C", "initials": "DC"}, {"family": "Li", "given": "Rui", "initials": "R"}, {"family": "Yu", "given": "Bingfei", "initials": "B"}, {"family": "Srinivasan", "given": "Suhas", "initials": "S"}, {"family": "Abe", "given": "Brian T", "initials": "BT"}, {"family": "Kraft", "given": "Katerina", "initials": "K"}, {"family": "Hellstr\u00f6m", "given": "Ceke", "initials": "C"}, {"family": "Sj\u00f6berg", "given": "Ronald", "initials": "R"}, {"family": "Chang", "given": "Sarah", "initials": "S"}, {"family": "Feng", "given": "Allan", "initials": "A"}, {"family": "Goldman", "given": "Daniel W", "initials": "DW"}, {"family": "Shah", "given": "Ami A", "initials": "AA"}, {"family": "Petri", "given": "Michelle", "initials": "M"}, {"family": "Chung", "given": "Lorinda S", "initials": "LS"}, {"family": "Fiorentino", "given": "David F", "initials": "DF"}, {"family": "Lundberg", "given": "Emma K", "initials": "EK"}, {"family": "Wutz", "given": "Anton", "initials": "A"}, {"family": "Utz", "given": "Paul J", "initials": "PJ"}, {"family": "Chang", "given": "Howard Y", "initials": "HY"}], "type": "journal article", "published": "2024-02-01", "journal": {"title": "Cell", "issn": "1097-4172", "volume": "187", "issue": "3", "pages": "733-749.e16", "issn-l": "0092-8674"}, "abstract": "Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to autoimmunity. Xist long non-coding RNA (lncRNA) is expressed only in females to randomly inactivate one of the two X chromosomes to achieve gene dosage compensation. Here, we show that the Xist ribonucleoprotein (RNP) complex comprising numerous autoantigenic components is an important driver of sex-biased autoimmunity. Inducible transgenic expression of a non-silencing form of Xist in male mice introduced Xist RNP complexes and sufficed to produce autoantibodies. Male SJL/J mice expressing transgenic Xist developed more severe multi-organ pathology in a pristane-induced lupus model than wild-type males. Xist expression in males reprogrammed T and B cell populations and chromatin states to more resemble wild-type females. Human patients with autoimmune diseases displayed significant autoantibodies to multiple components of XIST RNP. Thus, a sex-specific lncRNA scaffolds ubiquitous RNP components to drive sex-biased immunity.", "doi": "10.1016/j.cell.2023.12.037", "pmid": "38306984", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1961931"}, {"db": "pmc", "key": "PMC10949934"}, {"db": "pii", "key": "S0092-8674(24)00002-3"}], "notes": [], "created": "2026-09-23T06:42:45.257Z", "modified": "2026-09-23T06:42:45.289Z"}