{"entity": "publication", "iuid": "ce84b8d00dc54c979945224e9cb43304", "timestamp": "2026-09-26T23:31:50.845Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ce84b8d00dc54c979945224e9cb43304.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ce84b8d00dc54c979945224e9cb43304"}}, "title": "Mending Fences: Na,K-ATPase signaling via Ca2+ in the maintenance of epithelium integrity.", "authors": [{"family": "Aperia", "given": "Anita", "initials": "A"}, {"family": "Brismar", "given": "Hjalmar", "initials": "H", "orcid": "0000-0003-0578-4003", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04321d9fb805493db538489927a42c8f.json"}}, {"family": "Uhl\u00e9n", "given": "Per", "initials": "P", "orcid": "0000-0003-1446-1062", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ad7d29180614f89800a512887eeedd1.json"}}], "type": "journal article", "published": "2020-06-00", "journal": {"title": "Cell Calcium", "issn": "1532-1991", "volume": "88", "pages": "102210", "issn-l": null}, "abstract": "Na,K-ATPase is a ubiquitous multifunctional protein that acts both as an ion pump and as a signal transducer. The signaling function is activated by ouabain in non-toxic concentrations. In epithelial cells the ouabain-bound Na,K-ATPase connects with the inositol 1,4,5-trisphosphate receptor via a short linear motif to activate low frequency Ca2+ oscillations. Within a couple of minutes this ouabain mediated signal has resulted in phosphorylation or dephosphorylation of 2580 phospho-sites. Proteins that control cell proliferation and cell adhesion and calmodulin regulated proteins are enriched among the ouabain phosphor-regulated proteins. The inositol 1,4,5-trisphosphate receptor and the stromal interaction molecule, which are both essential for the initiation of Ca2+ oscillations, belong to the ouabain phosphor-regulated proteins. Downstream effects of the ouabain-evoked Ca2+ signal in epithelial cells include interference with the intrinsic mitochondrial apoptotic process and stimulation of embryonic growth processes. The dual function of Na,K-ATPase as an ion pump and a signal transducer is now well established and evaluation of the physiological and pathophysiological consequences of this universal signal emerges as an urgent topic for future studies.", "doi": "10.1016/j.ceca.2020.102210", "pmid": "32380435", "labels": [], "xrefs": [{"db": "pii", "key": "S0143-4160(20)30052-X"}], "notes": [], "created": "2026-09-23T11:58:15.248Z", "modified": "2026-09-23T14:51:55.244Z"}