{"entity": "publication", "iuid": "c88f1f4fc6244fa9bda510aa26f71faf", "timestamp": "2026-08-23T09:25:34.348Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c88f1f4fc6244fa9bda510aa26f71faf.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c88f1f4fc6244fa9bda510aa26f71faf"}}, "title": "A D-Y Shaped Neuropeptide Y Mimetic Peptide-Dye Self-Assembly with Maximal Emission Beyond 1300 nm and Glioma Mitochondrial Activity Modulation.", "authors": [{"family": "Li", "given": "Yanying", "initials": "Y"}, {"family": "He", "given": "Xuelu", "initials": "X"}, {"family": "Wang", "given": "Pin", "initials": "P"}, {"family": "Yuan", "given": "Bo", "initials": "B"}, {"family": "Pan", "given": "Yuanbo", "initials": "Y"}, {"family": "Hu", "given": "Xueyin", "initials": "X"}, {"family": "Lu", "given": "Liheng", "initials": "L"}, {"family": "Wu", "given": "Aiguo", "initials": "A", "orcid": "0000-0001-7200-8923", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af1ddb5c9be247788ad39a38878aa622.json"}}, {"family": "Li", "given": "Juan", "initials": "J", "orcid": "0000-0002-0692-3370", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c35d1b258641462c861bcff5f8ba5ecb.json"}}], "type": "journal article", "published": "2024-03-00", "journal": {"title": "Small", "issn": "1613-6829", "volume": "20", "issue": "13", "pages": "e2308621", "issn-l": "1613-6810"}, "abstract": "Neuropeptide Y (NPY), as one of the most abundant neuropeptides known, is widely distributed in the central and peripheral nervous system. However, most of the reported NPY-mimetic peptides are hard to cross the blood-brain barrier, target glioma mitochondria, and achieve self-assembly nanostructure in situ. Here, based on the \u03b1-helix structure of the novel chiral NPY-mimetic peptides D/LNPY(14), a Y-shaped peptide is designed with the sequences that can be recognized by enterokinase and achieved nanofibers conversion in glioma cell mitochondria. Coupling the Y-shaped NPY-mimetic peptide with the NIR-II fluorophore IR1048, a red-shifting of the fluorescence spectrum beyond 1300 nm is achieved through self-assembly. After the self-assembly in glioma mitochondria, the formed nanofibers can promote intracellular mitochondrial ROS production and extend the NIR-II fluorescence imaging time to at least 7 days in vivo. This work for the first time endows the self-assembly of \u03b1-helical-based chiral NPY-mimetic peptides, providing a novel strategy for glioma subcellular regulation enhanced antitumor treatment guided by NIR-II fluorescence imaging.", "doi": "10.1002/smll.202308621", "pmid": "38109130", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T11:04:54.856Z", "modified": "2026-08-21T11:04:54.984Z"}