{"entity": "publication", "iuid": "c702ed950ed548df8a3e8c0049bbb60b", "timestamp": "2026-10-02T02:24:32.732Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c702ed950ed548df8a3e8c0049bbb60b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c702ed950ed548df8a3e8c0049bbb60b"}}, "title": "Streptococcus pneumoniae Nasopharyngeal Carriage among PCV-10-Vaccinated HIV-1-Infected Children with Maintained Serological Memory in Ethiopia.", "authors": [{"family": "Lemma", "given": "Mahlet", "initials": "M"}, {"family": "Bekele", "given": "Yonas", "initials": "Y"}, {"family": "Petkov", "given": "Stefan", "initials": "S"}, {"family": "H\u00e4gglund", "given": "Moa", "initials": "M"}, {"family": "Petros", "given": "Beyene", "initials": "B"}, {"family": "Aseffa", "given": "Abraham", "initials": "A", "orcid": "0000-0002-8028-1150", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04f8e0d7916c41a89e2dd34fb1f4be8e.json"}}, {"family": "Howe", "given": "Rawleigh", "initials": "R"}, {"family": "Chiodi", "given": "Francesca", "initials": "F"}], "type": "journal article", "published": "2020-02-25", "journal": {"title": "Pathogens", "issn": "2076-0817", "volume": "9", "issue": "3", "issn-l": null}, "abstract": "Streptococcus pneumoniae (S. pneumoniae) vaccines have substantially reduced the burden of invasive pneumococcal diseases (IPDs) worldwide. Despite high coverage with S. pneumoniae vaccination, upper-respiratory-tract colonization by S. pneumoniae is still common. We assessed maintenance of serological responses to S. pneumoniae serotypes included in PCV-10 by ELISA in HIV-1-infected children (n = 50) and age-matched controls (n = 50) in Ethiopia. We isolated S. pneumoniae in nasopharyngeal swabs and determined S. pneumoniae serotype by whole genome sequencing (WGS). Comparable levels of S. pneumoniae serotype-specific IgG concentrations were detected in plasma of HIV-1-infected children and matched controls, with geometric mean concentrations (GMCs) consistently higher than the protective threshold for PCV-10 serotypes of 0.35 \u03bcg/mL. We isolated S. pneumoniae from 38 (out of 97) nasopharyngeal swabs, 25 from HIV-1-infected children and 13 from controls. WGS based serotyping revealed 22 known S. pneumoniae serotypes and 2 nontypeable (NT) isolates. Non-PCV-10 serotypes represented >90% of isolates. We showed that HIV-1-infected children and matched controls in Ethiopia carry a level of maintained serological memory to PCV-10 considered protective for IPDs. We identified a higher proportion of nasopharyngeal carriage with highly pathogenic S. pneumoniae non-PCV strains among HIV-1-infected children compared to controls.", "doi": "10.3390/pathogens9030159", "pmid": "32106620", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7157605"}, {"db": "pii", "key": "pathogens9030159"}], "notes": [], "created": "2026-09-23T13:12:55.422Z", "modified": "2026-09-23T13:12:55.494Z"}