{"entity": "publication", "iuid": "c3d82d05bd6b42d98f830850715080b4", "timestamp": "2026-10-01T11:59:47.224Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c3d82d05bd6b42d98f830850715080b4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c3d82d05bd6b42d98f830850715080b4"}}, "title": "Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection.", "authors": [{"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Svensson-Akusj\u00e4rvi", "given": "Sara", "initials": "S", "orcid": "0000-0002-1086-5409", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c201d2cd118d4556976ce7749b412b33.json"}}, {"family": "Krishnan", "given": "Shuba", "initials": "S"}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "Vesterbacka", "given": "Jan", "initials": "J"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Benfeitas", "given": "Rui", "initials": "R"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U", "orcid": "0000-0002-0844-3338", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/202f8d41f6694d67af0fd583b6b7f6e4.json"}}], "type": "journal article", "published": "2022-09-00", "journal": {"title": "Life Sci. Alliance", "issn": "2575-1077", "volume": "5", "issue": "9", "issn-l": null}, "abstract": "Genome-scale metabolic models (GSMMs) can provide novel insights into metabolic reprogramming during disease progression and therapeutic interventions. We developed a context-specific system-level GSMM of people living with HIV (PLWH) using global RNA sequencing data from PBMCs with suppressive viremia either by natural (elite controllers, PLWHEC) or drug-induced (PLWHART) control. This GSMM was compared with HIV-negative controls (HC) to provide a comprehensive systems-level metabo-transcriptomic characterization. Transcriptomic analysis identified up-regulation of oxidative phosphorylation as a characteristic of PLWHART, differentiating them from PLWHEC with dysregulated complexes I, III, and IV. The flux balance analysis identified altered flux in several intermediates of glycolysis including pyruvate, \u03b1-ketoglutarate, and glutamate, among others, in PLWHART The in vitro pharmacological inhibition of OXPHOS complexes in a latent lymphocytic cell model (J-Lat 10.6) suggested a role for complex IV in latency reversal and immunosenescence. Furthermore, inhibition of complexes I/III/IV induced apoptosis, collectively indicating their contribution to reservoir dynamics.", "doi": "10.26508/lsa.202201405", "pmid": "35537851", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9095731"}, {"db": "pii", "key": "5/9/e202201405"}, {"db": "figshare", "key": "10.6084/m9.figshare.19747582"}], "notes": [], "created": "2026-09-23T11:59:17.501Z", "modified": "2026-09-23T11:59:17.573Z"}