{"entity": "publication", "iuid": "bd732cd2ef6a405eb0281cd1654f1d28", "timestamp": "2026-09-01T08:31:27.791Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bd732cd2ef6a405eb0281cd1654f1d28.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bd732cd2ef6a405eb0281cd1654f1d28"}}, "title": "PD-L1ATTAC mice reveal the potential of depleting PD-L1 expressing cells in cancer therapy.", "authors": [{"family": "Fueyo-Marcos", "given": "Elena", "initials": "E"}, {"family": "Lopez-Pernas", "given": "Gema", "initials": "G"}, {"family": "Fustero-Torre", "given": "Coral", "initials": "C"}, {"family": "Ant\u00f3n", "given": "Marta Elena", "initials": "ME"}, {"family": "Al-Shahrour", "given": "F\u00e1tima", "initials": "F"}, {"family": "Fern\u00e1ndez-Capetillo", "given": "Oscar", "initials": "O"}, {"family": "Murga", "given": "Matilde", "initials": "M"}], "type": "journal article", "published": "2023-03-22", "journal": {"title": "Aging (Albany NY)", "issn": "1945-4589", "volume": "15", "issue": "6", "pages": "1791-1807", "issn-l": null}, "abstract": "Antibodies targeting the PD-1 receptor and its ligand PD-L1 have shown impressive responses in some tumors of bad prognosis. We hypothesized that, since immunosuppressive cells might present several immune checkpoints on their surface, the selective elimination of PD-L1 expressing cells could be efficacious in enabling the activation of antitumoral immune responses. To address this question, we developed an inducible suicidal knock-in mouse allele of Pd-l1 (PD-L1ATTAC) which allows for the tracking and specific elimination of PD-L1-expressing cells in adult tissues. Consistent with our hypothesis, elimination of PD-L1 expressing cells from the mouse peritoneum increased the septic response to lipopolysaccharide (LPS), due to an exacerbated inflammatory response to the endotoxin. In addition, mice depleted of PD-L1+ cells were resistant to colon cancer peritoneal allografts, which was associated with a loss of immunosuppressive B cells and macrophages, concomitant with an increase in activated cytotoxic CD8 T cells. Collectively, these results illustrate the usefulness of PD-L1ATTAC mice for research in immunotherapy and provide genetic support to the concept of targeting PD-L1 expressing cells in cancer.", "doi": "10.18632/aging.204598", "pmid": "36947705", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10085585"}, {"db": "pii", "key": "204598"}], "notes": [], "created": "2026-08-20T12:55:23.113Z", "modified": "2026-08-20T12:55:23.142Z"}