{"entity": "publication", "iuid": "bb3e36b10554433aa0726a66c17ac74e", "timestamp": "2026-08-29T04:16:50.150Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bb3e36b10554433aa0726a66c17ac74e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bb3e36b10554433aa0726a66c17ac74e"}}, "title": "A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes.", "authors": [{"family": "Dusart", "given": "Philip", "initials": "P"}, {"family": "Hallstr\u00f6m", "given": "Bj\u00f6rn Mikael", "initials": "BM"}, {"family": "Renn\u00e9", "given": "Thomas", "initials": "T"}, {"family": "Odeberg", "given": "Jacob", "initials": "J"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Butler", "given": "Lynn Marie", "initials": "LM"}], "type": "journal article", "published": "2019-11-05", "journal": {"title": "Cell Reports", "issn": "2211-1247", "volume": "29", "issue": "6", "pages": "1690-1706.e4", "issn-l": null}, "abstract": "Changes in the endothelium of the cerebral vasculature can contribute to inflammatory, thrombotic, and malignant disorders. The importance of defining cell-type-specific genes and their modification in disease is increasingly recognized. Here, we develop a bioinformatics-based approach to identify normal brain cell-enriched genes, using bulk RNA sequencing (RNA-seq) data from 238 normal human cortex samples from 2 independent cohorts. We compare endothelial cell-enriched gene profiles with astrocyte, oligodendrocyte, neuron, and microglial cell profiles. Endothelial changes in malignant disease are explored using RNA-seq data from 516 lower-grade gliomas and 401 glioblastomas. Lower-grade gliomas appear to be an \"endothelial intermediate\" between normal brain and glioblastoma. We apply our method for the prediction of glioblastoma-specific endothelial biomarkers, providing potential diagnostic or therapeutic targets. In summary, we provide a roadmap of endothelial cell identity in normal and malignant brain, using a method developed to resolve bulk RNA-seq into constituent cell-type-enriched profiles.", "doi": "10.1016/j.celrep.2019.09.088", "pmid": "31693905", "labels": [], "xrefs": [{"db": "pii", "key": "S2211-1247(19)31292-6"}], "notes": [], "created": "2026-08-20T06:51:01.636Z", "modified": "2026-08-20T06:51:01.698Z"}