{"entity": "publication", "iuid": "ba14291fe27d407ca35d423a0660be3f", "timestamp": "2026-08-26T22:47:04.665Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ba14291fe27d407ca35d423a0660be3f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ba14291fe27d407ca35d423a0660be3f"}}, "title": "TGFBR3L-An Uncharacterised Pituitary Specific Membrane Protein Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour Tissue.", "authors": [{"family": "Sj\u00f6stedt", "given": "Evelina", "initials": "E", "orcid": "0000-0002-0327-7377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec6fb5a1c88b44798144fd2de255fb00.json"}}, {"family": "Kolnes", "given": "Anders J", "initials": "AJ", "orcid": "0000-0003-4607-9642", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/479aad69241d4c85964bb9f41945fbb9.json"}}, {"family": "Olarescu", "given": "Nicoleta C", "initials": "NC"}, {"family": "Mitsios", "given": "Nicholas", "initials": "N"}, {"family": "Hikmet", "given": "Feria", "initials": "F"}, {"family": "Sivertsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Lindskog", "given": "Cecilia", "initials": "C"}, {"family": "\u00d8ystese", "given": "Kristin A B", "initials": "KAB", "orcid": "0000-0002-3147-6007", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a67f26c2257d44a0a31d2f8d3a9e695b.json"}}, {"family": "J\u00f8rgensen", "given": "Anders P", "initials": "AP", "orcid": "0000-0002-1246-9194", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bc5ad03de219408f8d8c71309d7e9466.json"}}, {"family": "Bollerslev", "given": "Jens", "initials": "J"}, {"family": "Casar-Borota", "given": "Olivera", "initials": "O", "orcid": "0000-0001-7376-7331", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be2f108c23f24ce6b661c0446eeb3134.json"}}], "type": "journal article", "published": "2020-12-31", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "13", "issue": "1", "issn-l": "2072-6694"}, "abstract": "Here, we report the investigation of transforming growth factor beta-receptor 3 like (TGFBR3L), an uncharacterised pituitary specific membrane protein, in non-neoplastic anterior pituitary gland and pituitary neuroendocrine tumours. A polyclonal antibody produced within the Human Protein Atlas project (HPA074356) was used for TGFBR3L staining and combined with SF1 and FSH for a 3-plex fluorescent protocol, providing more details about the cell lineage specificity of TGFBR3L expression. A cohort of 230 pituitary neuroendocrine tumours were analysed. In a subgroup of previously characterised gonadotroph tumours, correlation with expression of FSH/LH, E-cadherin, oestrogen (ER) and somatostatin receptors (SSTR) was explored. TGFBR3L showed membranous immunolabeling and was found to be gonadotroph cell lineage-specific, verified by co-expression with SF1 and FSH/LH staining in both tumour and non-neoplastic anterior pituitary tissues. TGFBR3L immunoreactivity was observed in gonadotroph tumours only and demonstrated intra-tumour heterogeneity with a perivascular location. TGFBR3L immunostaining correlated positively to both FSH (R = 0.290) and LH (R = 0.390) immunostaining, and SSTR3 (R = 0.315). TGFBR3L correlated inversely to membranous E-cadherin staining (R = -0.351) and oestrogen receptor \u03b2 mRNA (R = -0.274). In conclusion, TGFBR3L is a novel pituitary gland specific protein, located in the membrane of gonadotroph cells in non-neoplastic anterior pituitary gland and in a subset of gonadotroph pituitary tumours.", "doi": "10.3390/cancers13010114", "pmid": "33396509", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7795056"}, {"db": "pii", "key": "cancers13010114"}], "notes": [], "created": "2026-08-21T13:01:33.704Z", "modified": "2026-08-21T13:01:33.906Z"}