{"entity": "publication", "iuid": "b6939f3464fb4cdf8b3163af9e70c302", "timestamp": "2026-10-11T13:54:18.801Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b6939f3464fb4cdf8b3163af9e70c302.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b6939f3464fb4cdf8b3163af9e70c302"}}, "title": "The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia.", "authors": [{"family": "Mou", "given": "Tian", "initials": "T", "orcid": "0000-0001-7707-8760", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49095ca9ec09411f9e757b061ebb854b.json"}}, {"family": "Pawitan", "given": "Yudi", "initials": "Y"}, {"family": "Stahl", "given": "Matthias", "initials": "M"}, {"family": "Vesterlund", "given": "Mattias", "initials": "M"}, {"family": "Deng", "given": "Wenjiang", "initials": "W"}, {"family": "Jafari", "given": "Rozbeh", "initials": "R"}, {"family": "Bohlin", "given": "Anna", "initials": "A"}, {"family": "\u00d6sterroos", "given": "Albin", "initials": "A"}, {"family": "Siavelis", "given": "Loannis", "initials": "L"}, {"family": "B\u00e4ckvall", "given": "Helena", "initials": "H"}, {"family": "Erkers", "given": "Tom", "initials": "T"}, {"family": "Kiviluoto", "given": "Santeri", "initials": "S"}, {"family": "Seashore-Ludlow", "given": "Brinton", "initials": "B"}, {"family": "\u00d6stling", "given": "P\u00e4ivi", "initials": "P"}, {"family": "Orre", "given": "Lukas M", "initials": "LM"}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}, {"family": "Lehmann", "given": "S\u00f6ren", "initials": "S"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J"}, {"family": "Vu", "given": "Trung Nghia", "initials": "TN"}], "type": "comparative study", "published": "2021-05-01", "journal": {"title": "Am. J. Hematol.", "issn": "1096-8652", "volume": "96", "issue": "5", "pages": "580-588", "issn-l": "0361-8609"}, "abstract": "Molecular classification of acute myeloid leukemia (AML) aids prognostic stratification and clinical management. Our aim in this study is to identify transcriptome-wide mRNAs that are specific to each of the molecular subtypes of AML. We analyzed RNA-sequencing data of 955 AML samples from three cohorts, including the BeatAML project, the Cancer Genome Atlas, and a cohort of Swedish patients to provide a comprehensive transcriptome-wide view of subtype-specific mRNA expression. We identified 729 subtype-specific mRNAs, discovered in the BeatAML project and validated in the other two cohorts. Using unique proteomics data, we also validated the presence of subtype-specific mRNAs at the protein level, yielding a rich collection of potential protein-based biomarkers for the AML community. To enable the exploration of subtype-specific mRNA expression by the broader scientific community, we provide an interactive resource to the public.", "doi": "10.1002/ajh.26141", "pmid": "33625756", "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T11:17:06.347Z", "modified": "2026-09-23T11:17:06.445Z"}