{"entity": "publication", "iuid": "b3521dde375a4fb4842d7daf894471e3", "timestamp": "2026-10-01T22:39:21.546Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b3521dde375a4fb4842d7daf894471e3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b3521dde375a4fb4842d7daf894471e3"}}, "title": "Biodistribution and Radiation Dosimetry of the Anti-HER2 Affibody Molecule 68Ga-ABY-025 in Breast Cancer Patients.", "authors": [{"family": "Sandstr\u00f6m", "given": "Mattias", "initials": "M"}, {"family": "Lindskog", "given": "Karolina", "initials": "K"}, {"family": "Velikyan", "given": "Irina", "initials": "I"}, {"family": "Wennborg", "given": "Anders", "initials": "A"}, {"family": "Feldwisch", "given": "Joachim", "initials": "J"}, {"family": "Sandberg", "given": "Dan", "initials": "D"}, {"family": "Tolmachev", "given": "Vladimir", "initials": "V"}, {"family": "Orlova", "given": "Anna", "initials": "A"}, {"family": "S\u00f6rensen", "given": "Jens", "initials": "J"}, {"family": "Carlsson", "given": "J\u00f6rgen", "initials": "J"}, {"family": "Lindman", "given": "Henrik", "initials": "H"}, {"family": "Lubberink", "given": "Mark", "initials": "M"}], "type": "journal article", "published": "2016-06-00", "journal": {"title": "Journal of nuclear medicine : official publication, Society of Nuclear Medicine", "issn": "1535-5667", "volume": "57", "issue": "6", "pages": "867-871", "issn-l": "0161-5505"}, "abstract": "(68)Ga-ABY-025 is a radiolabeled Affibody molecule for in vivo diagnosis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer tumors with PET. The aim of the present work was to measure the biodistribution and estimate the radiation dosimetry of (68)Ga-ABY-025 for 2 different peptide mass doses in a single group of patients using dynamic and serial whole-body PET/CT.\n\nEight patients with metastatic breast cancer were included. Each patient underwent an abdominal 45-min dynamic and 3 whole-body PET/CT scans at 1, 2, and 4 h after injection of a low peptide dose (LD) and a high peptide dose (HD), with approximately the same amount of radioactivity, in separate investigations 1 wk apart. As input to the absorbed dose calculations, volumes of interest were drawn on all clearly identifiable source organs: liver, kidneys, spleen, descending aorta, and upper large intestine. Absorbed doses were calculated using OLINDA/EXM, version 1.1.\n\nOf the major organs, the highest radionuclide uptake at 1, 2, and 4 h after injection was observed in the kidneys and liver. The highest absorbed organ doses were seen in the kidneys, followed by the liver for both LD and HD (68)Ga-ABY-025. Absorbed doses to liver and kidneys were slightly but significantly higher for LD. Total effective dose was 0.030 \u00b1 0.003 mSv/MBq for LD and 0.028 \u00b1 0.002 mSv/MBq for HD.\n\nThe effective dose for a typical 200-MBq administration of (68)Ga-ABY-025 is 6.0 mSv for LD and 5.6 mSv for HD. Therefore, from a radiation dosimetry point of view, HD is preferred for PET/CT evaluation of HER2-expressing breast cancer tumors. These effective doses are somewhat higher than earlier published values for other (68)Ga-labeled tracers, such as 0.021 \u00b1 0.003 mSv/MBq for (68)Ga-DOTATATE and (68)Ga-DOTATOC, mainly because of higher uptake in liver and kidney.", "doi": "10.2967/jnumed.115.169342", "pmid": "26912439", "labels": [], "xrefs": [{"db": "pii", "key": "jnumed.115.169342"}], "notes": [], "created": "2026-09-23T07:38:00.977Z", "modified": "2026-09-23T07:38:01.031Z"}