{"entity": "publication", "iuid": "b261a8dff79843e4b50b37a829339303", "timestamp": "2026-08-26T23:01:22.340Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b261a8dff79843e4b50b37a829339303.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b261a8dff79843e4b50b37a829339303"}}, "title": "Imaging-based screens of pool-synthesized cell libraries.", "authors": [{"family": "Lawson", "given": "Michael", "initials": "M", "orcid": "0000-0002-2868-733X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7b13ef7ad1d14886809bfb3aafefb8d2.json"}}, {"family": "Elf", "given": "Johan", "initials": "J", "orcid": "0000-0001-5522-1810", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7001138c10bf4a6d84075057ba30c8b9.json"}}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Nat. Methods", "issn": "1548-7105", "volume": "18", "issue": "4", "pages": "358-365", "issn-l": "1548-7091"}, "abstract": "Mapping a genetic perturbation to a change in phenotype is at the core of biological research. Advances in microscopy have transformed these studies, but they have largely been confined to examining a few strains or cell lines at a time. In parallel, there has been a revolution in creating synthetic libraries of genetically altered cells with relative ease. Here we describe methods that combine these powerful tools to perform live-cell imaging of pool-generated strain libraries for improved biological discovery.", "doi": "10.1038/s41592-020-01053-8", "pmid": "33589838", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41592-020-01053-8"}], "notes": [], "created": "2026-08-20T09:02:29.211Z", "modified": "2026-08-20T09:02:29.295Z"}