{"entity": "publication", "iuid": "b1bcebcbaa5640c0adbf255264ecec66", "timestamp": "2026-10-01T11:59:47.818Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b1bcebcbaa5640c0adbf255264ecec66.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b1bcebcbaa5640c0adbf255264ecec66"}}, "title": "ER\u03b2 and Inflammation.", "authors": [{"family": "Hases", "given": "Linnea", "initials": "L"}, {"family": "Archer", "given": "Amena", "initials": "A"}, {"family": "Williams", "given": "Cecilia", "initials": "C"}], "type": "journal article", "published": "2022-09-16", "journal": {"title": "Springer", "issn": "0065-2598", "volume": "1390", "pages": "213-225", "issn-l": null}, "abstract": "Estrogen, through the regulation of cytokine production, can act both as pro-inflammatory and anti-inflammatory signals dependent on the tissue context. In breast cancer cells, ER\u03b1 is known to modulate inflammatory signaling through interaction with NF\u03baB. Whether ER\u03b2 has a role in inflammation is less explored. Low levels of ER\u03b2 have been corroborated in several immune-related organs and, for example, in colonic epithelial cells. Specifically, an impact of ER\u03b2 on colitis and colitis-associated colorectal cancer (CRC) is experimentally supported, using ER\u03b2-selective agonists, full-body ER\u03b2 knockout mice and, most recently, intestinal epithelial-specific knockout mice. An intricate crosstalk between ER\u03b2 and TNF\u03b1/NF\u03baB signaling in the colon is supported, and ER\u03b2 activation appears to reduce macrophage infiltration also during high fat diet (HFD)-induced colon inflammation. Finally, the gut microbiota plays a fundamental role in the pathogenesis of colitis and ER\u03b2 has been indicated to modulate the microbiota diversity during colitis and colitis-induced CRC. ER\u03b2 is thus proposed to protect against colitis, by modulating NF\u03baB signaling, immune cell infiltration, and/or microbiota composition. Selective activation of ER\u03b2 may therefore constitute a suitable preventative approach for the treatment of for example colitis-associated CRC.", "doi": "10.1007/978-3-031-11836-4_12", "pmid": "36107321", "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T11:08:45.103Z", "modified": "2026-09-23T11:08:45.144Z"}