{"entity": "publication", "iuid": "b1ba471d00a140ebb6828cb4e6261143", "timestamp": "2026-09-30T23:39:30.124Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b1ba471d00a140ebb6828cb4e6261143.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b1ba471d00a140ebb6828cb4e6261143"}}, "title": "Imaging of fibrogenesis in the liver by [18F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor \u03b2.", "authors": [{"family": "Wegrzyniak", "given": "Olivia", "initials": "O", "orcid": "0000-0001-9636-0390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/627311bb7c9f4d2e904eb3a6a62198bd.json"}}, {"family": "Zhang", "given": "Bo", "initials": "B"}, {"family": "Rokka", "given": "Johanna", "initials": "J"}, {"family": "Rosestedt", "given": "Maria", "initials": "M"}, {"family": "Mitran", "given": "Bogdan", "initials": "B"}, {"family": "Cheung", "given": "Pierre", "initials": "P"}, {"family": "Puuvuori", "given": "Emmi", "initials": "E"}, {"family": "Ingvast", "given": "Sofie", "initials": "S"}, {"family": "Persson", "given": "Jonas", "initials": "J"}, {"family": "Nordstr\u00f6m", "given": "Helena", "initials": "H"}, {"family": "L\u00f6fblom", "given": "John", "initials": "J"}, {"family": "Pont\u00e9n", "given": "Fredrik", "initials": "F"}, {"family": "Frejd", "given": "Fredrik Y", "initials": "FY"}, {"family": "Korsgren", "given": "Olle", "initials": "O"}, {"family": "Eriksson", "given": "Jonas", "initials": "J"}, {"family": "Eriksson", "given": "Olof", "initials": "O"}], "type": "journal article", "published": "2023-09-21", "journal": {"title": "EJNMMI Radiopharm Chem", "issn": "2365-421X", "volume": "8", "issue": "1", "pages": "23", "issn-l": null}, "abstract": "Platelet-derived growth factor receptor beta (PDGFR\u03b2) is a receptor overexpressed on activated hepatic stellate cells (aHSCs). Positron emission tomography (PET) imaging of PDGFR\u03b2 could potentially allow the quantification of fibrogenesis in fibrotic livers. This study aims to evaluate a fluorine-18 radiolabeled Affibody molecule ([18F]TZ-Z09591) as a PET tracer for imaging liver fibrogenesis.\n\nIn vitro specificity studies demonstrated that the trans-Cyclooctenes (TCO) conjugated Z09591 Affibody molecule had a picomolar affinity for human PDGFR\u03b2. Biodistribution performed on healthy rats showed rapid clearance of [18F]TZ-Z09591 through the kidneys and low liver background uptake. Autoradiography (ARG) studies on fibrotic livers from mice or humans correlated with histopathology results. Ex vivo biodistribution and ARG revealed that [18F]TZ-Z09591 binding in the liver was increased in fibrotic livers (p = 0.02) and corresponded to binding in fibrotic scars.\n\nOur study highlights [18F]TZ-Z09591 as a specific tracer for fibrogenic cells in the fibrotic liver, thus offering the potential to assess fibrogenesis clearly.", "doi": "10.1186/s41181-023-00210-6", "pmid": "37733133", "labels": {"SciLifeLab Fellow": "", "Olof Eriksson": ""}, "xrefs": [{"db": "pmc", "key": "PMC10513984"}, {"db": "pii", "key": "10.1186/s41181-023-00210-6"}], "notes": [], "created": "2026-09-23T11:01:57.422Z", "modified": "2026-09-23T11:01:57.460Z"}