{"entity": "publication", "iuid": "ad98c9e675ed454889c5113c7ea16838", "timestamp": "2026-09-23T16:07:11.054Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ad98c9e675ed454889c5113c7ea16838.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ad98c9e675ed454889c5113c7ea16838"}}, "title": "Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time.", "authors": [{"family": "Havervall", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-1671-8183", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb7ddbd0be2d4dca9249f55081fb86b3.json"}}, {"family": "Marking", "given": "Ulrika", "initials": "U"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Gordon", "given": "Max", "initials": "M"}, {"family": "Ng", "given": "Henry", "initials": "H"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Phillipson", "given": "Mia", "initials": "M"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a1bdfd8500c4dbea343132bc0d8e44c.json"}}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6265be732af0469d9d58bf5a46e8cf7d.json"}}, {"family": "Mangsbo", "given": "Sara", "initials": "S"}, {"family": "\u00c5berg", "given": "Mikael", "initials": "M"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}], "type": "journal article", "published": "2022-04-18", "journal": {"title": "Clin Transl Immunology", "issn": "2050-0068", "volume": "11", "issue": "4", "pages": "e1388", "issn-l": null}, "abstract": "To determine the long-term impact of prior SARS-CoV-2 infection on immune responses after COVID-19 vaccination.\n\nUsing longitudinally collected blood samples from the COMMUNITY study, we determined binding (WHO BAU mL-1) and neutralising antibody titres against ten SARS-CoV-2 variants over 7 months following BNT162b2 in SARS-CoV-2-recovered (n = 118) and SARS-CoV-2-na\u00efve (n = 289) healthcare workers with confirmed prior SARS-CoV-2 infection. A smaller group with (n = 47) and without (n = 60) confirmed prior SARS-CoV-2 infection receiving ChAdOx1 nCoV-19 was followed for 3 months. SARS-CoV-2-specific memory T-cell responses were investigated in a subset of SARS-CoV-2-na\u00efve and SARS-CoV-2-recovered vaccinees.\n\nVaccination with both vaccine platforms resulted in substantially enhanced T-cell responses, anti-spike IgG responses and neutralising antibodies effective against ten SARS-CoV-2 variants in SARS-CoV-2-recovered participants as compared to SARS-CoV-2-na\u00efve participants. The enhanced immune responses sustained over 7 months following vaccination.\n\nThese findings imply that prior SARS-CoV-2 infection should be taken into consideration when planning booster doses and design of current and future COVID-19 vaccine programmes.", "doi": "10.1002/cti2.1388", "pmid": "35444806", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9015077"}, {"db": "pii", "key": "CTI21388"}], "notes": [], "created": "2026-09-23T10:12:30.912Z", "modified": "2026-09-23T10:50:53.860Z"}