{"entity": "publication", "iuid": "ab1aaa7939914767a235cf175a5f4ddc", "timestamp": "2026-09-06T11:03:15.575Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ab1aaa7939914767a235cf175a5f4ddc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ab1aaa7939914767a235cf175a5f4ddc"}}, "title": "A novel cysteine-linked antibacterial surface coating significantly inhibits bacterial colonization of nasal silicone prongs in a phase one pre-clinical trial.", "authors": [{"family": "Odeberg", "given": "Jacob", "initials": "J"}, {"family": "Wirs\u00e9n", "given": "Anders", "initials": "A"}, {"family": "Norberg", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Frie", "given": "Jakob", "initials": "J"}, {"family": "Printz", "given": "Gordana", "initials": "G"}, {"family": "Lagercrantz", "given": "Hugo", "initials": "H"}, {"family": "Gudmundsson", "given": "Gudmundur H", "initials": "GH"}, {"family": "Agerberth", "given": "Birgitta", "initials": "B"}, {"family": "Jonsson", "given": "Baldvin", "initials": "B"}], "type": "clinical trial, phase i", "published": "2018-12-01", "journal": {"title": "Mater Sci Eng C Mater Biol Appl", "issn": "1873-0191", "volume": "93", "pages": "782-789", "issn-l": "0928-4931"}, "abstract": "Ventilator associated pneumonia and sepsis are frequent complications in neonatal care. Bacterial colonization of medical devices and interfaces used for respiratory support may contribute by functioning as a bacterial reservoir seeding bacteria into airways. We have developed an antibacterial surface coating based on a cysteine ligand covalently coupled via a spacer to a carboxylic backbone layer on an acrylic acid grafted silicone surface. This coating was applied on a commercially available nasal prong and the antibacterial effect was evaluated both in vitro and in vivo in a first-in-human phase 1 trial. The coated nasal prongs had strong antibacterial activity against both Gram-negative and Gram-positive bacteria in vitro. In a randomized pre-clinical trial study of 24 + 24 healthy adult volunteers who carried coated or non-coated nasal prongs for 18 h, a 10log difference in mean bacterial colonization of 5.82 (p < 0.0001) was observed. These results show that this coating technique can prevent colonization by the normal skin and mucosal flora, and thus represent a promising novel technology for reduction of medical device-associated hospital acquired infections.", "doi": "10.1016/j.msec.2018.08.040", "pmid": "30274112", "labels": [], "xrefs": [{"db": "pii", "key": "S0928-4931(17)34078-X"}], "notes": [], "created": "2026-08-20T08:01:44.385Z", "modified": "2026-08-20T08:01:44.427Z"}