{"entity": "publication", "iuid": "a756d35cde974f0098f1cf95baac8ccc", "timestamp": "2026-10-02T11:17:37.096Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a756d35cde974f0098f1cf95baac8ccc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a756d35cde974f0098f1cf95baac8ccc"}}, "title": "Hypoxia inducible factor-2\u03b1 importance for migration, proliferation, and self-renewal of trunk neural crest cells.", "authors": [{"family": "Niklasson", "given": "Camilla U", "initials": "CU"}, {"family": "Fredlund", "given": "Elina", "initials": "E"}, {"family": "Monni", "given": "Emanuela", "initials": "E"}, {"family": "Lindvall", "given": "Jessica M", "initials": "JM"}, {"family": "Kokaia", "given": "Zaal", "initials": "Z"}, {"family": "Hammarlund", "given": "Emma U", "initials": "EU"}, {"family": "Bronner", "given": "Marianne E", "initials": "ME"}, {"family": "Mohlin", "given": "Sofie", "initials": "S", "orcid": "0000-0002-2458-3963", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5138530b9de44c0bb5f93ba192da0cd9.json"}}], "type": "journal article", "published": "2021-02-00", "journal": {"title": "Dev. Dyn.", "issn": "1097-0177", "volume": "250", "issue": "2", "pages": "191-236", "issn-l": "1058-8388"}, "abstract": "The neural crest is a transient embryonic stem cell population. Hypoxia inducible factor (HIF)-2\u03b1 is associated with neural crest stem cell appearance and aggressiveness in tumors. However, little is known about its role in normal neural crest development.\n\nHere, we show that HIF-2\u03b1 is expressed in trunk neural crest cells of human, murine, and avian embryos. Knockdown as well as overexpression of HIF-2\u03b1 in vivo causes developmental delays, induces proliferation, and self-renewal capacity of neural crest cells while decreasing the proportion of neural crest cells that migrate ventrally to sympathoadrenal sites. Reflecting the in vivo phenotype, transcriptome changes after loss of HIF-2\u03b1 reveal enrichment of genes associated with cancer, invasion, epithelial-to-mesenchymal transition, and growth arrest.\n\nTaken together, these results suggest that expression levels of HIF-2\u03b1 must be strictly controlled during normal trunk neural crest development and that dysregulated levels affects several important features connected to stemness, migration, and development.", "doi": "10.1002/dvdy.253", "pmid": "32940375", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7891386"}], "notes": [], "created": "2026-09-23T08:48:05.818Z", "modified": "2026-09-23T08:48:05.884Z"}