{"entity": "publication", "iuid": "a70b6bc8aad0478a95ce32eac7c2e09d", "timestamp": "2026-08-29T04:15:57.061Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a70b6bc8aad0478a95ce32eac7c2e09d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a70b6bc8aad0478a95ce32eac7c2e09d"}}, "title": "HPV viral load in self-collected vaginal fluid samples as predictor for presence of cervical intraepithelial neoplasia.", "authors": [{"family": "Berggrund", "given": "Malin", "initials": "M"}, {"family": "Gustavsson", "given": "Inger", "initials": "I"}, {"family": "Aarnio", "given": "Riina", "initials": "R"}, {"family": "Hedlund-Lindberg", "given": "Julia", "initials": "J"}, {"family": "Sanner", "given": "Karin", "initials": "K"}, {"family": "Wikstr\u00f6m", "given": "Ingrid", "initials": "I"}, {"family": "Enroth", "given": "Stefan", "initials": "S"}, {"family": "Olovsson", "given": "Matts", "initials": "M"}, {"family": "Gyllensten", "given": "Ulf", "initials": "U", "orcid": "0000-0002-6316-3355", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eacfdf2095e947e99ac45fe994261b72.json"}}], "type": "evaluation study", "published": "2019-11-27", "journal": {"title": "Virol. J.", "issn": "1743-422X", "volume": "16", "issue": "1", "pages": "146", "issn-l": "1743-422X"}, "abstract": "This study was performed to evaluate the use of high-risk HPV (hrHPV) viral load in screening tests for cervical cancer to predict persistent infection and presence of cervical intraepithelial neoplasia grade 2 or worse (CIN2+).\n\nWe followed women between 30 and 60 years of age who performed self-sampling of vaginal fluid and subsequently a hrHPV test. Women who were hrHPV positive in their screening test repeated the hrHPV test 3-6 months later and were included in the present study.\n\nOur results show that women with a persistent HPV16 infection had higher HPV viral load in their primary screening test than women with transient infections (p = 5.33e-03). This was also true for sum of viral load for all hrHPV types in the primary screening test (p = 3.88e-07). 48% of women with persistent HPV16 infection and CIN2+ had an increase in HPV16 titer in the follow-up test, as compared to only 20% of women with persistent infection but without CIN2+ lesions. For the sum of all hrHPV types, 41% of women with persistent infection and CIN2+ had an increase in titer as compared to 26% of women without CIN2 + .\n\nThe results show that hrHPV viral load in the primary screening HPV test is associated with the presence of CIN2+ and could be used in triaging hrHPV positive women for different follow-up strategies or recall times. Serial testing of hrHPV viral load has the potential to distinguish women with CIN2+ lesions from women with persistent infection but without CIN2+ lesions.", "doi": "10.1186/s12985-019-1253-2", "pmid": "31771594", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6880361"}, {"db": "pii", "key": "10.1186/s12985-019-1253-2"}], "notes": [], "created": "2026-08-20T12:21:06.769Z", "modified": "2026-08-20T12:21:06.831Z"}