{"entity": "publication", "iuid": "9fbc1fdd722d474da00160b6eab355d9", "timestamp": "2026-08-23T09:24:52.391Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9fbc1fdd722d474da00160b6eab355d9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9fbc1fdd722d474da00160b6eab355d9"}}, "title": "Investigating chromosomal instability in long-term survivors with glioblastoma and grade 4 astrocytoma.", "authors": [{"family": "Spoor", "given": "Jochem K H", "initials": "JKH"}, {"family": "den Braber", "given": "May", "initials": "M"}, {"family": "Dirven", "given": "Clemens M F", "initials": "CMF"}, {"family": "Pennycuick", "given": "Adam", "initials": "A"}, {"family": "Bartkova", "given": "Jirina", "initials": "J"}, {"family": "Bartek", "given": "Jiri", "initials": "J"}, {"family": "van Dis", "given": "Vera", "initials": "V"}, {"family": "van den Bosch", "given": "Thierry P P", "initials": "TPP"}, {"family": "Leenstra", "given": "Sieger", "initials": "S"}, {"family": "Venkatesan", "given": "Subramanian", "initials": "S"}], "type": "journal article", "published": "2024-01-08", "journal": {"title": "Front Oncol", "issn": "2234-943X", "volume": "13", "pages": "1218297", "issn-l": "2234-943X"}, "abstract": "Only a small group of patients with glioblastoma multiforme (GBM) survives more than 36 months, so-called long-term survivors. Recent studies have shown that chromosomal instability (CIN) plays a prognostic and predictive role among different cancer types. Here, we compared histological (chromosome missegregation) and bioinformatic metrics (CIN signatures) of CIN in tumors of GBM typical survivors (\u226436 months overall survival), GBM long-term survivors and isocitrate dehydrogenase (IDH)-mutant grade 4 astrocytomas.\n\nTumor sections of all gliomas were examined for anaphases and chromosome missegregation. Further CIN signature activity analysis in the The Cancer Genome Atlas (TCGA)-GBM cohort was performed.\n\nOur data show that chromosome missegregation is pervasive in high grade gliomas and is not different between the 3 groups. We find only limited evidence of altered CIN levels in tumors of GBM long-term survivors relative to the other groups, since a significant depletion in CIN signature 11 relative to GBM typical survivors was the only alteration detected. In contrast, within IDH-mutant grade 4 astrocytomas we detected a significant enrichment of CIN signature 5 and 10 activities and a depletion of CIN signature 1 activity relative to tumors of GBM typical survivors.\n\nOur data suggest that CIN is pervasive in high grade gliomas, however this is unlikely to be a major contributor to the phenomenon of long-term survivorship in GBM. Nevertheless, further evaluation of specific types of CIN (signatures) could have prognostic value in patients suffering from grade 4 gliomas.", "doi": "10.3389/fonc.2023.1218297", "pmid": "38260852", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10800987"}], "notes": [], "created": "2026-08-21T13:00:27.987Z", "modified": "2026-08-21T13:00:28.009Z"}