{"entity": "publication", "iuid": "9f1740f733ee4ce79cdc1cdb0a7018a0", "timestamp": "2026-05-17T08:53:51.287Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9f1740f733ee4ce79cdc1cdb0a7018a0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9f1740f733ee4ce79cdc1cdb0a7018a0"}}, "title": "CADEE: Computer-Aided Directed Evolution of Enzymes.", "authors": [{"family": "Amrein", "given": "Beat Anton", "initials": "BA"}, {"family": "Steffen-Munsberg", "given": "Fabian", "initials": "F"}, {"family": "Szeler", "given": "Ireneusz", "initials": "I"}, {"family": "Purg", "given": "Miha", "initials": "M"}, {"family": "Kulkarni", "given": "Yashraj", "initials": "Y"}, {"family": "Kamerlin", "given": "Shina Caroline Lynn", "initials": "SCL"}], "type": "journal article", "published": "2017-01-01", "journal": {"volume": "4", "issn": "2052-2525", "issue": "Pt 1", "pages": "50-64", "title": "IUCrJ", "issn-l": "2052-2525"}, "abstract": "The tremendous interest in enzymes as biocatalysts has led to extensive work in enzyme engineering, as well as associated methodology development. Here, a new framework for computer-aided directed evolution of enzymes (CADEE) is presented which allows a drastic reduction in the time necessary to prepare and analyze in silico semi-automated directed evolution of enzymes. A pedagogical example of the application of CADEE to a real biological system is also presented in order to illustrate the CADEE workflow.", "doi": "10.1107/S2052252516018017", "pmid": "28250941", "labels": {"Affiliated researcher": null}, "xrefs": [{"db": "pii", "key": "be5274"}, {"db": "pmc", "key": "PMC5331465"}], "notes": [], "created": "2018-12-05T11:27:19.328Z", "modified": "2018-12-06T14:37:46.468Z"}