{"entity": "publication", "iuid": "9d36e5509b8e4f01bc243b357f88748a", "timestamp": "2026-08-26T22:47:32.810Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9d36e5509b8e4f01bc243b357f88748a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9d36e5509b8e4f01bc243b357f88748a"}}, "title": "Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.", "authors": [{"family": "Visnes", "given": "Torkild", "initials": "T"}, {"family": "Ben\u00edtez-Buelga", "given": "Carlos", "initials": "C"}, {"family": "C\u00e1zares-K\u00f6rner", "given": "Armando", "initials": "A"}, {"family": "Sanjiv", "given": "Kumar", "initials": "K"}, {"family": "Hanna", "given": "Bishoy M F", "initials": "BMF"}, {"family": "Mortusewicz", "given": "Oliver", "initials": "O"}, {"family": "Rajagopal", "given": "Varshni", "initials": "V"}, {"family": "Albers", "given": "Julian J", "initials": "JJ"}, {"family": "Hagey", "given": "Daniel W", "initials": "DW"}, {"family": "Bekkhus", "given": "Tove", "initials": "T"}, {"family": "Eshtad", "given": "Saeed", "initials": "S"}, {"family": "Baquero", "given": "Juan Miguel", "initials": "JM"}, {"family": "Masuyer", "given": "Geoffrey", "initials": "G"}, {"family": "Wallner", "given": "Olov", "initials": "O"}, {"family": "M\u00fcller", "given": "Sarah", "initials": "S"}, {"family": "Pham", "given": "Therese", "initials": "T"}, {"family": "G\u00f6kt\u00fcrk", "given": "Camilla", "initials": "C"}, {"family": "Rasti", "given": "Azita", "initials": "A"}, {"family": "Suman", "given": "Sharda", "initials": "S"}, {"family": "Torres-Ruiz", "given": "Ra\u00fal", "initials": "R"}, {"family": "Sarno", "given": "Antonio", "initials": "A"}, {"family": "Wiita", "given": "Elis\u00e9e", "initials": "E"}, {"family": "Homan", "given": "Evert J", "initials": "EJ"}, {"family": "Karsten", "given": "Stella", "initials": "S"}, {"family": "Marimuthu", "given": "Karthick", "initials": "K"}, {"family": "Michel", "given": "Maurice", "initials": "M"}, {"family": "Koolmeister", "given": "Tobias", "initials": "T"}, {"family": "Scobie", "given": "Martin", "initials": "M"}, {"family": "Loseva", "given": "Olga", "initials": "O"}, {"family": "Alml\u00f6f", "given": "Ingrid", "initials": "I"}, {"family": "Unterlass", "given": "Judith Edda", "initials": "JE"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Bostr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Pandey", "given": "Monica", "initials": "M"}, {"family": "Gad", "given": "Helge", "initials": "H"}, {"family": "Herr", "given": "Patrick", "initials": "P"}, {"family": "Jemth", "given": "Ann-Sofie", "initials": "AS"}, {"family": "El Andaloussi", "given": "Samir", "initials": "S"}, {"family": "Kalder\u00e9n", "given": "Christina", "initials": "C"}, {"family": "Rodriguez-Perales", "given": "Sandra", "initials": "S"}, {"family": "Ben\u00edtez", "given": "Javier", "initials": "J"}, {"family": "Krokan", "given": "Hans E", "initials": "HE"}, {"family": "Altun", "given": "Mikael", "initials": "M"}, {"family": "Stenmark", "given": "P\u00e5l", "initials": "P"}, {"family": "Berglund", "given": "Ulrika Warpman", "initials": "UW"}, {"family": "Helleday", "given": "Thomas", "initials": "T"}], "type": "journal article", "published": "2020-12-02", "journal": {"title": "Nucleic Acids Res.", "issn": "1362-4962", "volume": "48", "issue": "21", "pages": "12234-12251", "issn-l": "0305-1048"}, "abstract": "Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies on the upstream 8-oxoguanine-DNA glycosylase (OGG1) to recognise and excise 8-oxoG. Here we hypothesize that OGG1 may represent an attractive target to exploit reactive oxygen species (ROS) elevation in cancer. Although OGG1 depletion is well tolerated in non-transformed cells, we report here that OGG1 depletion obstructs A3 T-cell lymphoblastic acute leukemia growth in vitro and in vivo, validating OGG1 as a potential anti-cancer target. In line with this hypothesis, we show that OGG1 inhibitors (OGG1i) target a wide range of cancer cells, with a favourable therapeutic index compared to non-transformed cells. Mechanistically, OGG1i and shRNA depletion cause S-phase DNA damage, replication stress and proliferation arrest or cell death, representing a novel mechanistic approach to target cancer. This study adds OGG1 to the list of BER factors, e.g. PARP1, as potential targets for cancer treatment.", "doi": "10.1093/nar/gkaa1048", "pmid": "33211885", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7708037"}, {"db": "pii", "key": "5992293"}], "notes": [], "created": "2026-08-20T09:43:06.636Z", "modified": "2026-08-20T09:43:06.687Z"}