{"entity": "publication", "iuid": "99af8c0048074aec84ed49131df2397d", "timestamp": "2026-09-01T08:24:52.068Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/99af8c0048074aec84ed49131df2397d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/99af8c0048074aec84ed49131df2397d"}}, "title": "Monoclonal antibodies lock down SARS-CoV-2 spike.", "authors": [{"family": "Huang", "given": "Hsiang-Chi", "initials": "HC"}, {"family": "Angeletti", "given": "Davide", "initials": "D"}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "Trends Immunol.", "issn": "1471-4981", "volume": "44", "issue": "11", "pages": "874-876", "issn-l": "1471-4906"}, "abstract": "SARS-CoV-2 rapidly accumulated mutations in its immunodominant receptor-binding domain (RBD), rendering all clinically authorized monoclonal antibodies (mAbs) ineffective. Liu et al. unveil potent human mAbs that neutralize all tested SARS-CoV-2 variants by locking the Spike protein RBD in a downward conformation, thus inhibiting receptor engagement.", "doi": "10.1016/j.it.2023.09.006", "pmid": "37805348", "labels": [], "xrefs": [{"db": "pii", "key": "S1471-4906(23)00202-8"}], "notes": [], "created": "2026-08-20T07:58:08.561Z", "modified": "2026-08-20T07:58:08.625Z"}