{"entity": "publication", "iuid": "994f37819c8b47fba0698b68657a6cdb", "timestamp": "2026-06-08T10:59:12.657Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/994f37819c8b47fba0698b68657a6cdb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/994f37819c8b47fba0698b68657a6cdb"}}, "title": "Impact of CYP3A5*3 and CYP2C8-HapC on paclitaxel/carboplatin-induced myelosuppression in patients with ovarian cancer.", "authors": [{"family": "Gr\u00e9en", "given": "Henrik", "initials": "H"}, {"family": "Khan", "given": "Muhammad Suleman", "initials": "MS"}, {"family": "Jakobsen-Falk", "given": "Ingrid", "initials": "I"}, {"family": "\u00c5vall-Lundqvist", "given": "Elisabeth", "initials": "E"}, {"family": "Peterson", "given": "Curt", "initials": "C"}], "type": "journal article", "published": "2011-10-00", "journal": {"title": "J Pharm Sci", "issn": "1520-6017", "volume": "100", "issue": "10", "pages": "4205-4209", "issn-l": "0022-3549"}, "abstract": "The influence of genetic variants on paclitaxel-induced toxicity is of considerable interest for reducing adverse drug reactions. Recently, the genetic variants CYP2C8*3, CYP2C8-HapC, and CYP3A5*3 were associated with paclitaxel-induced neurotoxicity. We, therefore, investigated the impact of CYP2C8-HapC and CYP3A5*3 on paclitaxel/carboplatin-induced myelosuppression and neurotoxicity. Thirty-three patients from a prospective pharmacokinetics study were genotyped using pyrosequencing. Patients with variant alleles of CYP2C8-HapC were found to have significantly lower nadir values of both leukocytes and neutrophils (p < 0.05) than patients with the wild-type genotype. CYP3A5*3/*1 patients were shown to have borderline, significantly lower nadir values of leukocytes (p = 0.07) than *3/*3 patients. Combining the two genotypes resulted in a significant correlation with both leukopenia and neutropenia (p = 0.01). No effect of these genetic variants on neurotoxicity could be shown in this rather small study, but their importance for paclitaxel-induced toxicity could be confirmed.", "doi": "10.1002/jps.22680", "pmid": "21702053", "labels": {"Affiliated researcher": null}, "xrefs": [{"db": "pii", "key": "S0022-3549(15)31926-2"}], "notes": [], "created": "2018-12-05T09:44:03.501Z", "modified": "2018-12-05T09:44:03.535Z"}