{"entity": "publication", "iuid": "98e17ac6cfbb464397de183389b9b36a", "timestamp": "2026-08-20T20:42:18.161Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/98e17ac6cfbb464397de183389b9b36a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/98e17ac6cfbb464397de183389b9b36a"}}, "title": "Recurrent circuits encode de novo visual center-surround computations in the mouse superior colliculus.", "authors": [{"family": "Cui", "given": "Peng", "initials": "P"}, {"family": "Song", "given": "Kuisong", "initials": "K"}, {"family": "Mariatos-Metaxas", "given": "Dimitrios", "initials": "D"}, {"family": "Isla", "given": "Arturo G", "initials": "AG"}, {"family": "Femenia", "given": "Teresa", "initials": "T"}, {"family": "Lazaridis", "given": "Iakovos", "initials": "I"}, {"family": "Meletis", "given": "Konstantinos", "initials": "K"}, {"family": "Kumar", "given": "Arvind", "initials": "A"}, {"family": "Kardamakis", "given": "Andreas A", "initials": "AA", "orcid": "0000-0001-6821-5858", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4c7830accf0b4f89a03bc33da8837cc6.json"}}], "type": "journal article", "published": "2025-10-00", "journal": {"title": "PLoS Biol.", "issn": "1545-7885", "volume": "23", "issue": "10", "pages": "e3003414", "issn-l": "1544-9173"}, "abstract": "Models of visual salience detection rely on center-surround interactions, yet it remains unclear how these computations are distributed across retinal, cortical, and subcortical circuits due to their overlapping contributions. Here, we reveal a de novo collicular mechanism for surround suppression by combining patterned optogenetics with whole-cell recordings from individual neurons in the mouse superficial superior colliculus (SCs). Center zones were defined by monosynaptic input from channelrhodopsin-expressing retinal ganglion cells in collicular midbrain slices. Surround network optoactivation suppressed center responses compared to center-only input. This suppression is excitatory in origin, arising from the withdrawal of center excitation via surround-driven inhibition of local recurrent excitatory circuits, as demonstrated by cell-type-specific trans-synaptic tracing and computational modeling. These findings identify a local circuit mechanism for saliency computation in the SCs, independent of cortical input.", "doi": "10.1371/journal.pbio.3003414", "pmid": "41100444", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12530612"}, {"db": "pii", "key": "PBIOLOGY-D-24-03815"}], "notes": [], "created": "2026-08-20T12:42:41.976Z", "modified": "2026-08-20T12:42:42.068Z"}