{"entity": "publication", "iuid": "96bed561919341d7900da3bfe3ccd19a", "timestamp": "2026-09-01T08:24:40.502Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/96bed561919341d7900da3bfe3ccd19a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/96bed561919341d7900da3bfe3ccd19a"}}, "title": "The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch.", "authors": [{"family": "Gao", "given": "Tianle", "initials": "T"}, {"family": "Ma", "given": "Haisha", "initials": "H"}, {"family": "Xu", "given": "Bo", "initials": "B"}, {"family": "Bergman", "given": "Jessica", "initials": "J"}, {"family": "Larhammar", "given": "Dan", "initials": "D"}, {"family": "Lagerstr\u00f6m", "given": "Malin Charlotta", "initials": "MC"}], "type": "journal article", "published": "2018-11-00", "journal": {"title": "J. Invest. Dermatol.", "issn": "1523-1747", "volume": "138", "issue": "11", "pages": "2405-2411", "issn-l": "0022-202X"}, "abstract": "Itch is a somatosensory modality that serves to alert an organism to harmful elements removable by scratching, such as parasites and chemical irritants. Recently, ablation or silencing of neuropeptide Y (NPY)-expressing spinal interneurons was reported to selectively enhance mechanical itch, whereas chemical itch was unaffected. We examined the effect of activating the NPY/Y1 receptor system on scratch behavior in mice. We found that intrathecal administration of the Y1 agonist [Leu31,Pro34]-NPY (LP-NPY) attenuated itch behavior induced by application of 0.07 g von Frey filament in the nape of the neck compared with saline treatment, indicating that activation of the spinal NPY/Y1 system dampens mechanical itch. However, intrathecal administration of LP-NPY also attenuated chemically induced scratching provoked by intradermal application of histamine or the mast cell degranulator 48/80 (histaminergic itch), and the latter effect could be reversed by administration of the Y1 antagonist BIBO3304. Intrathecal application of the native nonselective agonist NPY also attenuated histamine or 48/80-induced scratching. Our analyses emphasize the importance of including additional quantitative parameters to characterize the full spectrum of itch behavior and show that the NPY/Y1 system dampens both mechanically and chemically induced scratching and hence is shared by the two submodalities of itch.", "doi": "10.1016/j.jid.2018.05.008", "pmid": "29803641", "labels": [], "xrefs": [{"db": "pii", "key": "S0022-202X(18)31981-X"}], "notes": [], "created": "2026-08-21T11:22:19.825Z", "modified": "2026-08-21T11:22:19.854Z"}