{"entity": "publication", "iuid": "94749511a1af4f1288260ef79e094937", "timestamp": "2026-09-27T17:02:51.618Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/94749511a1af4f1288260ef79e094937.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/94749511a1af4f1288260ef79e094937"}}, "title": "A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants.", "authors": [{"family": "J\u00e4\u00e4skel\u00e4inen", "given": "Tiina", "initials": "T", "orcid": "0000-0002-1202-0936", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e439a70676347eda81e94985610bc08.json"}}, {"family": "K\u00e4rkk\u00e4inen", "given": "Olli", "initials": "O", "orcid": "0000-0003-0825-4956", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/426277b567ed4ac8bc5b140baa1ab72f.json"}}, {"family": "Jokkala", "given": "Jenna", "initials": "J"}, {"family": "Litonius", "given": "Kaisa", "initials": "K"}, {"family": "Heinonen", "given": "Seppo", "initials": "S"}, {"family": "Auriola", "given": "Seppo", "initials": "S"}, {"family": "Lehtonen", "given": "Marko", "initials": "M"}, {"family": "Hanhineva", "given": "Kati", "initials": "K"}, {"family": "Laivuori", "given": "Hannele", "initials": "H", "orcid": "0000-0003-3212-7826", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b627627610c94358bb52aa3b31cbea7b.json"}}, {"family": "FINNPEC", "given": "", "initials": ""}], "type": "journal article", "published": "2018-10-02", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "8", "issue": "1", "pages": "14616", "issn-l": "2045-2322"}, "abstract": "Preeclampsia (PE) is a complex pregnancy disorder. It is not extensively known how the metabolic alterations of PE women contribute to the metabolism of newborn. We applied liquid chromatography-mass spectrometry (LC-MS) based non-targeted metabolomics to determine whether the metabolic profile of plasma from umbilical cord differs between infants born to PE and non-PE pregnancies in the FINNPEC study. Cord plasma was available from 42 newborns born from PE and 53 from non-PE pregnancies. 133 molecular features differed between PE and non-PE newborns after correction for multiple testing. Decreased levels of 4-pyridoxic acid were observed in the cord plasma samples of PE newborns when compared to non-PE newborns. Compounds representing following areas of metabolism were increased in the cord plasma of PE newborns: urea and creatine metabolism; carnitine biosynthesis and acylcarnitines; putrescine metabolites; tryptophan metabolism and phosphatidylcholines. To our knowledge, this study is the first one to apply LC-MS based metabolomics in cord plasma of PE newborns. We demonstrate that this strategy provides a global picture of the widespread metabolic alterations associated with PE and particularly the elevated levels of carnitine precursors and trimethylated compounds appear to be associated with PE at birth.", "doi": "10.1038/s41598-018-32804-5", "pmid": "30279541", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6168522"}, {"db": "pii", "key": "10.1038/s41598-018-32804-5"}], "notes": [], "created": "2026-09-23T09:45:44.693Z", "modified": "2026-09-23T10:19:58.217Z"}