{"entity": "publication", "iuid": "92b2294da5c942fd9f1708c1ec16066c", "timestamp": "2026-08-25T13:40:08.032Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/92b2294da5c942fd9f1708c1ec16066c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/92b2294da5c942fd9f1708c1ec16066c"}}, "title": "Combination treatment with anti-RANKL and antibiotics for preventing joint destruction in septic arthritis.", "authors": [{"family": "Hu", "given": "Zhicheng", "initials": "Z"}, {"family": "Deshmukh", "given": "Meghshree", "initials": "M"}, {"family": "Jarneborn", "given": "Anders", "initials": "A"}, {"family": "Bollmann", "given": "Miriam", "initials": "M"}, {"family": "Corciulo", "given": "Carmen", "initials": "C"}, {"family": "Kopparapu", "given": "Pradeep Kumar", "initials": "PK"}, {"family": "Ali", "given": "Abukar", "initials": "A"}, {"family": "Svensson", "given": "Mattias N D", "initials": "MND"}, {"family": "Engdahl", "given": "Cecilia", "initials": "C"}, {"family": "Pullerits", "given": "Rille", "initials": "R"}, {"family": "Mohammad", "given": "Majd", "initials": "M"}, {"family": "Jin", "given": "Tao", "initials": "T"}], "type": "journal article", "published": "2025-03-24", "journal": {"title": "JCI Insight", "issn": "2379-3708", "volume": "10", "issue": "6", "issn-l": null}, "abstract": "Septic arthritis, the most severe joint disease, is frequently caused by Staphylococcus aureus (S. aureus). A substantial proportion of patients with septic arthritis experience poor joint outcomes, often necessitating joint replacement surgery. Here, we show that monocyte depletion confers full protection against bone erosion in a septic arthritis mouse model. In the infected synovium, Ly6Chi monocytes exhibited increased expression of osteoclastogenesis-related molecules, including CCR2, c-Fms, and RANK. S. aureus lipoproteins induced elevated levels of RANKL, MCSF, and CCL2 in joints, with synovial fibroblasts identified as the major RANKL producer. Anti-RANKL treatment prevented bone destruction in both local and hematogenous septic arthritis murine models. Importantly, combining anti-RANKL treatment with antibiotics provided robust protection against joint damage. Our results indicate that the infiltration and transformation of monocytes into bone-destructive, osteoclast-like cells are key mechanisms in septic arthritis. Combining anti-RANKL and antibiotic therapy represents a promising therapy against this devastating disease.", "doi": "10.1172/jci.insight.184954", "pmid": "40067374", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11949037"}, {"db": "pii", "key": "184954"}], "notes": [], "created": "2026-08-21T12:31:53.234Z", "modified": "2026-08-21T12:31:53.263Z"}