{"entity": "publication", "iuid": "909d30e2c6c24070928df7138071fa91", "timestamp": "2026-08-20T20:50:23.330Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/909d30e2c6c24070928df7138071fa91.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/909d30e2c6c24070928df7138071fa91"}}, "title": "Major cardiovascular events and death in parents of children with type 1 diabetes: a register-based matched cohort study in Sweden.", "authors": [{"family": "Kennedy", "given": "Beatrice", "initials": "B", "orcid": "0000-0002-0066-4814", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb88fcd6bead49978b129dffe779d8a0.json"}}, {"family": "Wernroth", "given": "Mona-Lisa", "initials": "ML", "orcid": "0000-0002-8845-8846", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/228e6d16e2e44389b0dc548584616a70.json"}}, {"family": "Batra", "given": "Gorav", "initials": "G", "orcid": "0000-0002-2480-9547", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/39554aefe1494e3389140d3dbee4ffa9.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U", "orcid": "0000-0001-8367-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b833fa7c77f542aabd5b04f4d9c02afd.json"}}, {"family": "Linroth", "given": "Cecilia", "initials": "C", "orcid": "0009-0005-3308-9886", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b35ee5eda63444448e0e790c21ac8d5d.json"}}, {"family": "Gr\u00f6nberg", "given": "Annika", "initials": "A", "orcid": "0000-0002-8502-8568", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0442565cd22a4d2e917c8649acc659da.json"}}, {"family": "Byberg", "given": "Liisa", "initials": "L", "orcid": "0000-0002-4421-6466", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/079e2e50ce7a4bc8ae14ecf7512a415d.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "journal article", "published": "2024-09-00", "journal": {"title": "Diabetologia", "issn": "1432-0428", "volume": "67", "issue": "9", "pages": "1828-1837", "issn-l": "0012-186X"}, "abstract": "Parenting a child with type 1 diabetes has been associated with stress-related symptoms. This study aimed to elucidate the potential impact on parental risk of major cardiovascular events (MCE) and death.\n\nIn this register-based study, we included the parents of 18,871 children, born 1987-2020 and diagnosed with type 1 diabetes in Sweden at <18 years. The median parental age at the child's diagnosis was 39.0 and 41.0 years for mothers and fathers, respectively. The cohort also encompassed 714,970 population-based matched parental control participants and 12,497 parental siblings. Cox proportional hazard regression models were employed to investigate the associations between having a child with type 1 diabetes and incident MCE and all-cause death, and, as secondary outcomes, acute coronary syndrome and ischaemic heart disease (IHD). We adjusted for potential confounders including parental type 1 diabetes and country of birth.\n\nDuring follow-up (median 12 years, range 0-35), we detected no associations between parenting a child with type 1 diabetes and MCE in mothers (adjusted HR [aHR] 1.02; 95% CI 0.90, 1.15) or in fathers (aHR 1.01; 95% CI 0.94, 1.08). We noted an increased hazard of IHD in exposed mothers (aHR 1.21; 95% CI 1.05, 1.41) with no corresponding signal in fathers (aHR 0.97; 95% CI 0.89, 1.05). Parental sibling analysis did not confirm the association in exposed mothers (aHR 1.01; 95% CI 0.73, 1.41). We further observed a slightly increased hazard of all-cause death in exposed fathers (aHR 1.09; 95% CI 1.01, 1.18), with a similar but non-significant estimate noted in exposed mothers (aHR 1.07; 95% CI 0.96, 1.20). The estimates from the sibling analyses of all-cause death in fathers and mothers were 1.12 (95% CI 0.90, 1.38) and 0.73 (95% CI 0.55, 0.96), respectively.\n\nHaving a child diagnosed with type 1 diabetes in Sweden was not associated with MCE, but possibly with all-cause mortality. Further studies are needed to disentangle potential underlying mechanisms, and to investigate parental health outcomes across the full lifespan.", "doi": "10.1007/s00125-024-06200-w", "pmid": "38922417", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11410917"}, {"db": "pii", "key": "10.1007/s00125-024-06200-w"}], "notes": [], "created": "2026-08-20T06:38:57.222Z", "modified": "2026-08-20T06:38:57.511Z"}