{"entity": "publication", "iuid": "8e7e8105ce8f4c538d586a79c705472d", "timestamp": "2026-08-26T22:47:27.678Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8e7e8105ce8f4c538d586a79c705472d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8e7e8105ce8f4c538d586a79c705472d"}}, "title": "Early increment of soluble triggering receptor expressed on myeloid cells 2 in plasma might be a predictor of poor outcome after ischemic stroke.", "authors": [{"family": "Kwon", "given": "Hyuk Sung", "initials": "HS"}, {"family": "Lee", "given": "Eun-Hye", "initials": "EH"}, {"family": "Park", "given": "Hyun-Hee", "initials": "HH"}, {"family": "Jin", "given": "Jeong-Hwa", "initials": "JH"}, {"family": "Choi", "given": "Hojin", "initials": "H"}, {"family": "Lee", "given": "Kyu-Yong", "initials": "KY"}, {"family": "Lee", "given": "Young Joo", "initials": "YJ"}, {"family": "Lee", "given": "Jae-Hong", "initials": "JH"}, {"family": "de Oliveira", "given": "Felipe Marques Souza", "initials": "FMS"}, {"family": "Kim", "given": "Hyun Young", "initials": "HY"}, {"family": "Seo Kim", "given": "Young", "initials": "Y"}, {"family": "Kim", "given": "Bum Joon", "initials": "BJ"}, {"family": "Heo", "given": "Sung Hyuk", "initials": "SH"}, {"family": "Chang", "given": "Dae-Il", "initials": "DI"}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M"}, {"family": "Koh", "given": "Seong-Ho", "initials": "SH"}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "J Clin Neurosci", "issn": "1532-2653", "volume": "73", "pages": "215-218", "issn-l": null}, "abstract": "Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is derived from cleavage of TREM2, which is expressed on the cell surface of microlgia and other tissue-specific macrophages. In the present study, the changes in the sTREM2 levels after ischemic stroke (IS) and their association with clinical outcomes were evaluated. A total of 43 patients diagnosed with non-cardioembolic IS between June 2011 and May 2014 were consecutively included in this study. Patients treated with intravenous thrombolysis or intra-arterial thrombectomy were excluded. Plasma samples were collected three times (days 1, 7, and 90) after ictus. The sTREM2 level was measured in the samples using the highly sensitive solid-phase proximity ligation assay (SP-PLA). Among the 43 subjects, higher initial NIH stroke scale (NIHSS) score (P = 0.005), early increment of sTREM2 (P < 0.001), and late decrement of sTREM2 (P = 0.002), were more common in patients with poor outcome. Based on multivariate analysis, initial NIHSS score (P = 0.015) and early increment of sTREM2 (P = 0.032) were independently associated with poor outcome. The results from the present study indicate that increment of sTREM2 level at the early phase was a predictor of poor outcome. Serial follow-up of sTREM2 may aid prognosis after stroke.", "doi": "10.1016/j.jocn.2020.02.016", "pmid": "32067825", "labels": [], "xrefs": [{"db": "pii", "key": "S0967-5868(19)32350-1"}], "notes": [], "created": "2026-08-20T08:00:02.877Z", "modified": "2026-08-20T08:00:02.947Z"}