{"entity": "publication", "iuid": "8b38928cafa24a6387b16e43bfa5d411", "timestamp": "2026-08-29T04:17:13.018Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8b38928cafa24a6387b16e43bfa5d411.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8b38928cafa24a6387b16e43bfa5d411"}}, "title": "Activation of Oncogenic Super-Enhancers Is Coupled with DNA Repair by RAD51.", "authors": [{"family": "Hazan", "given": "Idit", "initials": "I"}, {"family": "Monin", "given": "Jonathan", "initials": "J"}, {"family": "Bouwman", "given": "Britta A M", "initials": "BAM"}, {"family": "Crosetto", "given": "Nicola", "initials": "N"}, {"family": "Aqeilan", "given": "Rami I", "initials": "RI"}], "type": "journal article", "published": "2019-10-15", "journal": {"title": "Cell Reports", "issn": "2211-1247", "volume": "29", "issue": "3", "pages": "560-572.e4", "issn-l": null}, "abstract": "DNA double-strand breaks (DSBs) are deleterious and tumorigenic but could also be essential for DNA-based processes. Yet the landscape of physiological DSBs and their role and repair are still elusive. Here, we mapped DSBs at high resolution in cancer and non-tumorigenic cells and found a transcription-coupled repair mechanism at oncogenic super-enhancers. At these super-enhancers the transcription factor TEAD4, together with various transcription factors and co-factors, co-localizes with the repair factor RAD51 of the homologous recombination pathway. Depletion of TEAD4 or RAD51 increases DSBs at RAD51/TEAD4 common binding sites within super-enhancers and decreases expression of related genes, which are mostly oncogenes. Co-localization of RAD51 with transcription factors at super-enhancers occurs in various cell types, suggesting a broad phenomenon. Together, our findings uncover a coupling between transcription and repair mechanisms at oncogenic super-enhancers, to control the hyper-transcription of multiple cancer drivers.", "doi": "10.1016/j.celrep.2019.09.001", "pmid": "31618627", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6899447"}, {"db": "pii", "key": "S2211-1247(19)31169-6"}], "notes": [], "created": "2026-08-21T11:15:52.988Z", "modified": "2026-08-21T11:15:53.009Z"}