{"entity": "publication", "iuid": "802b4d38eda945dea38c11481e23dd9f", "timestamp": "2026-09-23T15:30:38.282Z", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/802b4d38eda945dea38c11481e23dd9f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/802b4d38eda945dea38c11481e23dd9f"}}, "title": "Idiopathic inflammatory myopathies lack neutralising autoantibodies to type- I, II and III interferons.", "authors": [{"family": "Behere", "given": "Anish", "initials": "A", "orcid": "0000-0002-2424-3475", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c220e32442f343deb55eb3a1aa1865e0.json"}}, {"family": "Mildner", "given": "Hedvig", "initials": "H"}, {"family": "Peralta Garcia", "given": "Irene", "initials": "I"}, {"family": "P\u00e9rez Bucio", "given": "C\u00e9sar", "initials": "C"}, {"family": "Lundberg", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-6068-9212", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2891140c49d446dbd82c96857bcde73.json"}}, {"family": "Horuluoglu", "given": "Begum", "initials": "B"}, {"family": "Landegren", "given": "Nils", "initials": "N"}], "type": "journal article", "published": "2025-09-25", "journal": {"title": "RMD Open", "issn": "2056-5933", "volume": "11", "issue": "3", "issn-l": null}, "abstract": "To determine whether autoantibodies against interferons are present and play a role in disease modulation in idiopathic inflammatory myopathies (IIMs).\n\nWe screened for autoantibodies against a large number of interferons (IFNs) and other cytokines in a cross-sectional observational cohort of Swedish patients with anti-synthetase syndrome (n=51) and dermatomyositis (n=48), matched together with blood donors (n=100) from general population, using both planar and suspension-based multiplex assays. A single patient with autoimmune polyendocrine syndrome, type-1 (APS-1), known to harbour autoantibodies that neutralise type-I interferons, was included as a reference biological positive. The functional ability of autoantibodies to neutralise type-I interferons was tested in vitro, using an IFN-\u03b1/\u03b2 responsive cell reporter assay.\n\nThe initial screening of plasma samples indicated a repertoire of autoantibodies in IIM patients against a number of common myositis-specific and myositis-associated antigens. On screening for autoantibodies against type-I, II or III interferons, we did not find any evidence of anti-IFN autoantibodies being present in any of the IIM patient subgroups or the blood donors from general population. Additionally, none of the tested plasma samples, except the APS-1, exhibited neutralisation of physiological concentration IFN-\u03b12, further confirming a complete lack of functional autoantibodies against IFN-\u03b1 subtypes in this cohort.\n\nWe did not detect neutralising autoantibodies against IFN-\u03b1 and autoantibodies against other types of IFNs in a Swedish cohort of IIM patients. These findings contrast with the presence of autoantibodies against type-I IFNs in other systemic autoimmune diseases, such as systemic lupus erythematosus, characterised by type-I IFN overactivation.", "doi": "10.1136/rmdopen-2025-005836", "pmid": "40998521", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12481268"}, {"db": "pii", "key": "rmdopen-2025-005836"}], "notes": [], "created": "2026-09-23T12:35:45.217Z", "modified": "2026-09-23T12:35:45.283Z"}